Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28397299 | 0.85 | SRC (0.59) | CYP19A1MEN1KMT2ACASP3SENP8 | |
| SCHEMBL23038402 | 0.83 | CYP1A2 (0.51) | CYP1A2CYP2C9CYP2C19CYP19A1SRC | |
| SCHEMBL20046983 | 0.82 | CYP1A2 (0.53) | CYP1A2CYP2C9CYP2C19NPC1RAB9A | |
| SCHEMBL22959003 | 0.82 | SRC (0.58) | CYP19A1MEN1KMT2ACASP3SENP8 | |
| SCHEMBL13307575 | 0.81 | POLB (0.53) | CYP19A1MEN1KMT2ACASP3SENP8 | |
| SCHEMBL23047930 | 0.79 | CYP1A2 (0.50) | CYP1A2CYP2C9CYP2C19CYP19A1KMT2A | |
| SCHEMBL28330048 | 0.79 | CYP19A1 (0.60) | CYP19A1MEN1KMT2ACASP3SENP8 | |
| SCHEMBL23048071 | 0.78 | CYP1A2 (0.49) | CYP1A2CYP2C9CYP2C19CYP19A1SRC | |
| SCHEMBL23038547 | 0.77 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP2C19SRCNPC1 | |
| SCHEMBL30556704 | 0.77 | SRC (0.58) | CYP19A1MEN1KMT2ACASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507769-B2 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | SCRIPPS RESEARCH INST (US) | 2017-10-11 | — | — | EP | disclosed |
| US-20160214946-A1 | CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-07-28 | — | — | US | disclosed |
| US-9302997-B2 | Copper-catalysed ligation of azides and acetylenes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-04-05 | — | — | US | disclosed |
| EP-2226316-B1 | Copper-catalysed ligation of azides and acetylenes | SCRIPPS RESEARCH INST (US) | 2016-01-13 | — | — | EP | disclosed |
| US-20150232432-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-08-20 | — | — | US | disclosed |
| US-9040716-B2 | Copper-catalysed ligation of azides and acetylenes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-05-26 | — | — | US | disclosed |
| US-20150031895-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-01-29 | — | — | US | disclosed |
| US-8877939-B2 | Copper-catalysed ligation of azides and acetylenes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-11-04 | — | — | US | disclosed |
| US-20140066632-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-03-06 | — | — | US | disclosed |
| US-8580970-B2 | Copper-catalysed ligation of azides and acetylenes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-11-12 | — | — | US | disclosed |
| US-20120165542-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-06-28 | — | — | US | disclosed |
| US-8129542-B2 | Copper-catalysed ligation of azides and acetylenes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110105764-A1 | Copper-catalysed ligation of azides and acetylenes | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-05-05 | — | — | US | disclosed |
| EP-2226316-A1 | Copper-catalysed ligation of azides and acetylenes | The Scripps Research Institute (US) | 2010-09-08 | — | — | EP | disclosed |
| US-7763736-B2 | Contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole; high yields and high purity | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-07-27 | — | — | US | disclosed |
| US-20080214831-A1 | Contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole; high yields and high purity | THE SCRIPPS RESEARCH INSTITUTE | 2008-09-04 | — | — | US | disclosed |
| US-7375234-B2 | regiospecifically ligates azides and terminal acetylenes to give only 1,4-disubstituted [1,2,3]-triazoles; stepwise Huisgen cycloaddition process catalyzed by copper | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-05-20 | — | — | US | disclosed |
| WO-2007001335-A2 | RAMOPLANIN DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY | VICURON PHARMACEUTICALS INC. (US) | 2007-01-04 | — | — | WO | disclosed |
| US-20060211603-A1 | Ramoplanin derivatives possessing antibacterial activity | VICURON PHARMACEUTICALS INC. (US) | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232432-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | SOD1, AOC3, AOC2 | CYP1A2 355/4885CYP2C9 1049/4885CYP2C19 702/4885 |
| US-20080214831-A1 | Contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole; high yields and high purity | AOC3, AOC2, ADH1C | CYP1A2 463/4885CYP2C9 1346/4885CYP2C19 1123/4885 |
| US-20120165542-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | AOC3, ADH1C, AOC2 | CYP1A2 245/4885CYP2C9 657/4885CYP2C19 652/4885 |
| US-20160214946-A1 | CATALYSED LIGATION OF AZIDES AND ACETYLENES | AOC3, AOC2, KARS1 | CYP1A2 143/4885CYP2C9 370/4885CYP2C19 228/4885 |
| US-20110105764-A1 | Copper-catalysed ligation of azides and acetylenes | AOC3, ADH1C, AOC2 | CYP1A2 245/4885CYP2C9 657/4885CYP2C19 652/4885 |
| US-20150031895-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | AOC3, SOD1, AOC2 | CYP1A2 344/4885CYP2C9 423/4885CYP2C19 217/4885 |
| US-20060211603-A1 | Ramoplanin derivatives possessing antibacterial activity | CLSPN, LMAN2, RPN2 | CYP1A2 4174/4885CYP2C9 4299/4885CYP2C19 4445/4885 |
| US-20140066632-A1 | COPPER-CATALYSED LIGATION OF AZIDES AND ACETYLENES | AOC3, SOD1, AOC2 | CYP1A2 344/4885CYP2C9 423/4885CYP2C19 217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.