Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5327792 | 0.94 | HTR6 (0.52) | HTR6CYP3A4CYP2D6HSD17B10KMT2A | |
| SCHEMBL5336272 | 0.91 | HSD17B10 (0.45) | HTR6HSD17B10KMT2AKDM4EALDH1A1 | |
| SCHEMBL5335199 | 0.90 | HTR6 (0.46) | HTR6HSD17B10KMT2AKDM4EALDH1A1 | |
| SCHEMBL5333246 | 0.90 | POLB (0.45) | HTR6CYP3A4CYP2D6HSD17B10KMT2A | |
| SCHEMBL5333836 | 0.88 | HTR6 (0.52) | HTR6CYP3A4CYP2D6KMT2AMPO | |
| SCHEMBL5335593 | 0.87 | MPO (0.46) | HTR6CYP3A4CYP2D6MPOKDM4E | |
| SCHEMBL5330544 | 0.86 | HTR6 (0.43) | HTR6HSD17B10KMT2AMPOKDM4E | |
| SCHEMBL5332975 | 0.86 | HTR6 (0.50) | HTR6KMT2AALDH1A1 | |
| SCHEMBL5333028 | 0.86 | MPO (0.47) | HTR6CYP3A4CYP2D6MPO | |
| SCHEMBL5329261 | 0.84 | HTR6 (0.49) | HTR6CYP3A4CYP2D6KMT2AMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007046112-A1 | ARYLTHIOETHER TRYPTAMINE DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS | SUVEN LIFE SCIENCES INC. (IN) | 2007-04-26 | — | — | WO | claimed |
| WO-2007046112-A1 | ARYLTHIOETHER TRYPTAMINE DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS | SUVEN LIFE SCIENCES INC. (IN) | 2007-04-26 | — | — | WO | disclosed |