Sugi Predict

Sugi Predict / Compounds / SCHEMBL5335430

SCHEMBL5335430

SCHEMBL5335430

C=C(C)C(=O)OC(C)c1ccc(O)c(-n2nc3ccccc3n2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 8/20 0.48
▸ RAB9A P51151 8/20 0.48
▸ LMNA P02545 1/20 0.48
▸ ALDH1A1 P00352 5/20 0.39
▸ SMN1; SMN2 Q16637 5/20 0.39
▸ MAPT P10636 5/20 0.34
▸ KDM4E B2RXH2 4/20 0.34
▸ HPGD P15428 2/20 0.34
▸ TDP1 Q9NUW8 2/20 0.34
▸ POLB P06746 3/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ GPR139 Q6DWJ6 1/20 0.33
▸ USP2 O75604 1/20 0.33
▸ PPARG P37231 1/20 0.31
▸ PPARA Q07869 1/20 0.31
▸ CASP3 P42574 1/20 0.31
▸ SENP7 Q9BQF6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25409014 0.88 NPC1 (0.36) NPC1RAB9ALMNAALDH1A1MAPT
SCHEMBL25409470 0.87 NPC1 (0.35) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
SCHEMBL25410636 0.86 NPC1 (0.34) NPC1RAB9ALMNAALDH1A1HPGD
SCHEMBL25411021 0.85 NPC1 (0.45) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
SCHEMBL25408407 0.85 MEN1 (0.53) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
SCHEMBL3479788 0.85 NPC1 (0.34) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL6535795 0.84 NPC1 (0.48) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
SCHEMBL7113989 0.84 NPC1 (0.43) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
SCHEMBL25412296 0.84 NPC1 (0.43) NPC1RAB9ALMNAALDH1A1SMN1; SMN2
SCHEMBL31025719 0.83 NPC1 (0.45) NPC1RAB9ALMNAALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114058142-B Transparent fluorine-containing polymer film 浙江省化工研究院有限公司 2023-05-12 — — CN claimed
CN-114058142-A Transparent fluorine-containing polymer film 浙江省化工研究院有限公司 2022-02-18 — — CN claimed
US-20260147141-A1 SURFACE MODIFIED SILICONE OPHTHALMIC DEVICES BAUSCH + LOMB IRELAND LIMITED (IE) 2026-05-28 — — US disclosed
US-20260078209-A1 SILICONE HYDROGEL INK BINDER FOR CONTACT LENSES BAUSCH & LOMB IRELAND LTD (IE) 2026-03-19 — — US disclosed
US-20260054913-A1 CONTACT LENSES HAVING CATIONIC MONOMERS OR CATIONIC POLYMERS FOR RELEASING COMFORT AGENTS CITIBANK, N.A., AS NOTES COLLATERAL AGENT 2026-02-26 — — US disclosed
US-20260022282-A1 ACTINIC RADIATION AND MOISTURE DUAL CURABLE EPOXY COMPOSITIONS DYMAX CORPORATION (US) 2026-01-22 — — US disclosed
EP-4041131-B1 ADJUSTABLE INTRAOCULAR LENSES ALCON INC (CH) 2025-12-10 — — EP disclosed
US-20250334718-A1 SURFACE MODIFIED SILICONE OPHTHALMIC DEVICE BAUSCH & LOMB IRELAND LTD (IE) 2025-10-30 — — US disclosed
US-20250318920-A1 ADJUSTABLE INTRAOCULAR LENSES AND METHODS OF POST-OPERATIVELY ADJUSTING INTRAOCULAR LENSES ALCON INC. (CH) 2025-10-16 — — US disclosed
EP-4631540-A2 ADJUSTABLE INTRAOCULAR LENSES Alcon Inc. (CH) 2025-10-15 — — EP disclosed
US-12370040-B2 Adjustable intraocular lenses and methods of post-operatively adjusting intraocular lenses ALCON INC. (CH) 2025-07-29 — — US disclosed
US-8969429-B2 Low-tack, hydrophobic ophthalmic device materials NOVARTIS AG (CH) 2015-03-03 — — US disclosed
EP-2673666-B1 LOW-TACK, HYDROPHOBIC OPHTHALMIC DEVICE MATERIALS NOVARTIS AG (CH) 2014-12-31 — — EP disclosed
US-8557892-B2 Hydrophobic acrylic intraocular lens materials NOVARTIS AG (CH) 2013-10-15 — — US disclosed
US-8466209-B2 Hydrophobic acrylic intraocular lens materials NOVARTIS AG (CH) 2013-06-18 — — US disclosed
US-20120309919-A1 HYDROPHOBIC ACRYLIC INTRAOCULAR LENS MATERIALS NOVARTIS AG (CH) 2012-12-06 — — US disclosed
US-20120309899-A1 HYDROPHOBIC ACRYLIC INTRAOCULAR LENS MATERIALS NOVARTIS AG (CH) 2012-12-06 — — US disclosed
US-20120202916-A1 Low-Tack, Hydrophobic Ophthalmic Device Materials NOVARTIS AG (CH) 2012-08-09 — — US disclosed
US-7211622-B2 Aqueous resin composition and its uses NIPPON SHOKUBAI CO., LTD. (JP) 2007-05-01 — — US disclosed
US-20040241484-A1 Aqueous resin composition and its uses NIPPON SHOKUBAI CO., LTD. (JP) 2004-12-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260054913-A1 CONTACT LENSES HAVING CATIONIC MONOMERS OR CATIONIC POLYMERS FOR RELEASING COMFORT AGENTS TRPA1, ASIC1, ARGLU1 NPC1 3457/4885RAB9A 2294/4885LMNA 2720/4885
US-20260078209-A1 SILICONE HYDROGEL INK BINDER FOR CONTACT LENSES CRYAA, CRYAB, CRYZ NPC1 4493/4885RAB9A 1614/4885LMNA 2144/4885
US-20260147141-A1 SURFACE MODIFIED SILICONE OPHTHALMIC DEVICES EPCAM, STIM1, SMCHD1 NPC1 1618/4885RAB9A 1823/4885LMNA 2741/4885
US-20260022282-A1 ACTINIC RADIATION AND MOISTURE DUAL CURABLE EPOXY COMPOSITIONS RAD51, CDH1, GNE NPC1 4778/4885RAB9A 2343/4885LMNA 2514/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.