Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 known ✓ | Q9Y271 | 9/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.38 |
| ▸ | ABCC2 | Q92887 | 2/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5336081 | 1.00 | CYSLTR1 (0.40) | CYSLTR1CYSLTR2ABCC1ABCC2TBXA2R | |
| SCHEMBL5333732 | 0.94 | CYSLTR1 (0.45) | CYSLTR1CYSLTR2ABCC1ABCC2TBXA2R | |
| SCHEMBL5333735 | 0.94 | CYSLTR1 (0.45) | CYSLTR1CYSLTR2ABCC1ABCC2TBXA2R | |
| SCHEMBL5332207 | 0.91 | CYSLTR1 (0.41) | CYSLTR1CYSLTR2ABCC1ABCC2TBXA2R | |
| SCHEMBL5332200 | 0.91 | CYSLTR1 (0.41) | CYSLTR1CYSLTR2ABCC1ABCC2TBXA2R | |
| SCHEMBL5336822 | 0.88 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2ABCC1ABCC2 | |
| SCHEMBL5336828 | 0.88 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2ABCC1ABCC2 | |
| SCHEMBL5339124 | 0.86 | CYSLTR1 (0.45) | CYSLTR1CYSLTR2ABCC1ABCC2 | |
| SCHEMBL5339118 | 0.86 | CYSLTR1 (0.45) | CYSLTR1CYSLTR2ABCC1ABCC2 | |
| SCHEMBL7245580 | 0.86 | CYSLTR1 (0.40) | CYSLTR1CYSLTR2ABCC1ABCC2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309718-B2 | Dibenzocycloheptene compound | UBE INDUSTRIES, LTD. (JP) | 2007-12-18 | — | — | US | disclosed |
| EP-1408033-A1 | DIBENZOCYCLOHEPTENE COMPOUND | Ube Industries, Ltd. (JP) | 2004-04-14 | — | — | EP | disclosed |