Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5328871 | 0.91 | DRD2 (0.47) | HTR6DRD2DRD4DRD3CYP3A4 | |
| SCHEMBL5329261 | 0.86 | HTR6 (0.49) | HTR6DRD2DRD4DRD3CYP3A4 | |
| SCHEMBL5335447 | 0.85 | DRD2 (0.50) | HTR6DRD2DRD4DRD3CYP3A4 | |
| SCHEMBL5335619 | 0.82 | MAPT (0.45) | HTR6DRD2DRD4DRD3POLB | |
| SCHEMBL5333246 | 0.78 | POLB (0.45) | HTR6DRD2DRD4DRD3CYP3A4 | |
| SCHEMBL5337329 | 0.77 | DRD2 (0.44) | HTR6DRD2DRD4DRD3POLB | |
| SCHEMBL5333140 | 0.74 | HTR6 (0.48) | HTR6POLB | |
| SCHEMBL5333028 | 0.74 | MPO (0.47) | HTR6DRD2DRD4DRD3CYP3A4 | |
| SCHEMBL5333822 | 0.73 | MAPT (0.45) | HTR6DRD2DRD4DRD3CHRNA7 | |
| SCHEMBL5336272 | 0.73 | HSD17B10 (0.45) | HTR6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007046112-A1 | ARYLTHIOETHER TRYPTAMINE DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS | SUVEN LIFE SCIENCES INC. (IN) | 2007-04-26 | — | — | WO | claimed |
| WO-2007046112-A1 | ARYLTHIOETHER TRYPTAMINE DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS | SUVEN LIFE SCIENCES INC. (IN) | 2007-04-26 | — | — | WO | disclosed |