Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 4/20 | 0.61 |
| ▸ | KDR | P35968 | 4/20 | 0.61 |
| ▸ | FLT4 | P35916 | 3/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 6/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | VCP | P55072 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5339170 | 0.88 | FLT1 (0.53) | FLT1KDRFLT4PIK3CAMAOA | |
| SCHEMBL14465941 | 0.84 | IMPDH2 (0.61) | FLT1KDRFLT4PIK3CAIMPDH2 | |
| SCHEMBL5337614 | 0.84 | PIK3CA (0.54) | FLT1KDRFLT4PIK3CAIMPDH2 | |
| SCHEMBL5317045 | 0.84 | VCP (0.63) | FLT1KDRFLT4PIK3CAIMPDH2 | |
| SCHEMBL5336680 | 0.82 | IMPDH2 (0.59) | FLT1KDRFLT4PIK3CAIMPDH2 | |
| SCHEMBL5338142 | 0.81 | VCP (0.65) | FLT1KDRFLT4PIK3CAIMPDH2 | |
| SCHEMBL5343138 | 0.81 | TRPV1 (0.53) | FLT1KDRFLT4IMPDH2ROCK2 | |
| SCHEMBL5318247 | 0.81 | IMPDH2 (0.57) | FLT1KDRFLT4PIK3CAIMPDH2 | |
| SCHEMBL5319685 | 0.81 | IMPDH2 (0.54) | FLT1KDRFLT4PIK3CAIMPDH2 | |
| SCHEMBL5350220 | 0.80 | VCP (0.67) | PIK3CAMAOAMAOBIMPDH2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |