Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 4/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | FLT4 | P35916 | 3/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5340970 | 0.88 | FLT1 (0.61) | FLT1KDRFLT4MAOAMAOB | |
| SCHEMBL5333863 | 0.85 | VCP (0.58) | FLT1KDRFLT4ROCK2IMPDH2 | |
| SCHEMBL5335613 | 0.85 | CDC7 (0.58) | FLT1KDRFLT4MAOBROCK2 | |
| SCHEMBL5333205 | 0.85 | IMPDH2 (0.53) | FLT1KDRFLT4ROCK2IMPDH2 | |
| SCHEMBL5316809 | 0.85 | NOS1 (0.48) | FLT1KDRFLT4ROCK2IMPDH2 | |
| SCHEMBL5343891 | 0.85 | VCP (0.58) | FLT1KDRFLT4ROCK2IMPDH2 | |
| SCHEMBL5336433 | 0.85 | MKNK1 (0.51) | FLT1KDRFLT4ROCK2IMPDH2 | |
| SCHEMBL5336680 | 0.85 | IMPDH2 (0.59) | FLT1KDRFLT4IMPDH2PIK3CA | |
| SCHEMBL14465941 | 0.85 | IMPDH2 (0.61) | FLT1KDRFLT4IMPDH2PIK3CA | |
| SCHEMBL5318416 | 0.82 | TNIK (0.60) | FLT1KDRFLT4ROCK2IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |