Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5347182 | 0.87 | PDE3B (0.66) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL5342355 | 0.84 | PDE3B (0.63) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL9464109 | 0.76 | KDM4E (0.76) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| Dimethylamine SCHEMBL9463919 | 0.73 | KDM4E (0.71) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL7326991 | 0.69 | P2RY12 (0.80) | PDE3BPDE3AP2RY12PRKDC | |
| SCHEMBL6156974 | 0.68 | ERAP1 (0.58) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL9229883 | 0.67 | PRKDC (0.52) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL6155892 | 0.67 | MAOB (0.58) | KDM4EALDH1A1HPGDGAACA12 | |
| SCHEMBL9463863 | 0.66 | KDM4E (0.80) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL3805551 | 0.66 | HTR1A (0.61) | ALDH1A1MAPTHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312210-B2 | Pyrrolo[2,1-c][1,4]benzodiazepine compounds and processes for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-12-25 | — | — | US | disclosed |
| WO-2007054954-A1 | A NOVEL PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRID AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2007-05-18 | — | — | WO | disclosed |
| US-20070082891-A1 | Novel pyrrolo[2,1-C] [1,4] benzodiazepine compounds and processes for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082891-A1 | Novel pyrrolo[2,1-C] [1,4] benzodiazepine compounds and processes for the preparation thereof | GABRA1, GABRA4, GABRA2 | PDE3B 2044/4885PDE3A 2275/4885KDM4E 402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.