Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.39 |
| ▸ | CCKBR | P32239 | 3/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14288682 | 0.85 | ALPL (0.47) | CCKBRKMT2APPARGWDR5 | |
| SCHEMBL532999 | 0.85 | TP53 (0.48) | KMT2ATP53SLC22A12 | |
| SCHEMBL534065 | 0.79 | PKM (0.53) | KMT2AWDR5 | |
| SCHEMBL532939 | 0.77 | EDNRA (0.43) | KMT2AMAPTPOLB | |
| SCHEMBL533018 | 0.76 | ALDH1A1 (0.51) | CCKBRKMT2ATP53ERAP1MAPT | |
| SCHEMBL532980 | 0.75 | JAK2 (0.48) | KMT2ATP53PPARGMAPTPOLB | |
| SCHEMBL532038 | 0.74 | ALDH1A1 (0.54) | KMT2ATP53MAPTPOLB | |
| SCHEMBL533057 | 0.74 | ALPL (0.44) | KMT2ASLC22A12MAPT | |
| SCHEMBL533957 | 0.73 | TP53 (0.39) | KMT2ATP53ERAP1MAPTPOLB | |
| SCHEMBL533091 | 0.72 | BRPF1 (0.52) | KMT2ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415760-A2 | CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |