Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11063011 | 0.87 | KDM4E (0.44) | KDM4EALDH1A1PKMADORA2AADORA1 | |
| SCHEMBL4552901 | 0.86 | KDM4E (0.45) | KDM4EALDH1A1PKMADORA2AADORA1 | |
| SCHEMBL11323139 | 0.73 | L3MBTL1 (0.56) | KDM4EALDH1A1ADORA2AADORA1TSHR | |
| SCHEMBL11699502 | 0.73 | TSHR (0.58) | KDM4EALDH1A1PKMADORA2AADORA1 | |
| SCHEMBL6760429 | 0.72 | KDM4E (0.81) | KDM4EALDH1A1PKMTSHRKMT2A | |
| SCHEMBL568868 | 0.72 | KDM4E (0.72) | KDM4EALDH1A1PKMTSHRCYP19A1 | |
| SCHEMBL3555850 | 0.70 | — | — | |
| SCHEMBL6755827 | 0.69 | KDM4E (0.57) | KDM4EALDH1A1PKMKMT2AMAPK1 | |
| SCHEMBL11654507 | 0.69 | KDM4E (0.58) | KDM4EALDH1A1PKMLMNAPOLB | |
| SCHEMBL1491110 | 0.68 | KDM4E (1.00) | KDM4EALDH1A1PKMTSHRCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070130702-A1 | Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative | L'OREAL S.A. | 2007-06-14 | — | — | US | claimed |
| EP-1434552-A1 | METHOD FOR DYEING KERATINOUS FIBRES | Henkel Kommanditgesellschaft auf Aktien (DE) | 2004-07-07 | — | — | EP | claimed |
| WO-2003030841-A1 | METHOD FOR DYEING KERATINOUS FIBRES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2003-04-17 | — | — | WO | claimed |
| US-11312722-B2 | Hsp90 inhibitors and uses thereof | TRUSTEES OF BOSTON UNIVERSITY (US) | 2022-04-26 | — | — | US | disclosed |
| US-20200354373-A1 | HSP90 INHIBITORS AND USES THEREOF | TRUSTEES OF BOSTON UNIVERSITY (US) | 2020-11-12 | — | — | US | disclosed |
| EP-2753615-B1 | BENZONITRILE DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2017-07-19 | — | — | EP | disclosed |
| US-8969335-B2 | Benzonitrile derivatives as kinase inhibitors | MERCK PATENT GMBH (DE) | 2015-03-03 | — | — | US | disclosed |
| US-20140228340-A1 | BENZONITRILE DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2014-08-14 | — | — | US | disclosed |
| CN-103930416-A | Benzonitrile derivatives as kinase inhibitors | MERCK PATENT GMBH | 2014-07-16 | — | — | CN | disclosed |
| WO-2013034238-A1 | BENZONITRILE DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2013-03-14 | — | — | WO | disclosed |
| US-20070130702-A1 | Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative | L'OREAL S.A. | 2007-06-14 | — | — | US | disclosed |
| EP-0036100-B1 | NICKEL COMPLEX DYESTUFFS | BASF Aktiengesellschaft (DE) | 1983-06-15 | — | — | EP | disclosed |
| US-4246410-A | BENZINDOLE DYES OF YELLOW AND RED | CIBA -GEIGY AKTIENGESELLSCHAFT (CH) | 1981-01-20 | — | — | US | disclosed |
| US-4115394-A | ANTIINFLAMMATORY AGENTS, DIURETICS | E. R. SQUIBB & SONS, INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-3987051-A | Method for producing 1-unsubstituted pyrazolo[3,4-b]pyridine ketones | E. R. SQUIBB & SONS, INC. (US) | 1976-10-19 | — | — | US | disclosed |
| US-3985757-A | ANTIINFLAMMATORY AGENTS AND TRANQUILIZERS | E. R. SQUIBB & SONS, INC. (US) | 1976-10-12 | — | — | US | disclosed |
| US-3983128-A | CNS DEPRESSANTS, ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1976-09-28 | — | — | US | disclosed |
| US-3979399-A | ATARACTIC, ANALGESIC, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-09-07 | — | — | US | disclosed |
| US-3966746-A | ATARACTIC, ANALGESIC, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1976-06-29 | — | — | US | disclosed |
| US-3957782-A | Pyrazolo [3,4-b]pyrazine-5-carboxylic acids, esters, nitriles and amides | E. R. SQUIBB & SONS, INC. (US) | 1976-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070130702-A1 | Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative | KRT18, NDUFB5, NDUFB7 | KDM4E 440/4885ALDH1A1 83/4885PKM 196/4885 |
| US-20140228340-A1 | BENZONITRILE DERIVATIVES AS KINASE INHIBITORS | TBK1, NFKBIA, IKBKG | KDM4E 347/4885ALDH1A1 3279/4885PKM 429/4885 |
| US-20200354373-A1 | HSP90 INHIBITORS AND USES THEREOF | HSP90AB1, HSP90B1, HSP90AA1 | KDM4E 1421/4885ALDH1A1 2482/4885PKM 3236/4885 |
| US-11312722-B2 | Hsp90 inhibitors and uses thereof | HSP90AB1, HSP90B1, HSP90AA1 | KDM4E 1421/4885ALDH1A1 2482/4885PKM 3236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.