Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 2/20 | 0.35 |
| ▸ | CES1 | P23141 | 2/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 3/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA4 | P22748 | 2/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5364750 | 0.86 | TRPV4 (0.38) | ALDH1A1TRPV4CES2CES1TAS1R3 | |
| SCHEMBL3552234 | 0.85 | KEAP1 (0.39) | TRPV4CES2CES1STAT3MAOA | |
| SCHEMBL14408161 | 0.83 | STAT3 (0.36) | ALDH1A1ALOX15TRPV4CES2CES1 | |
| SCHEMBL7044003 | 0.83 | DGAT1 (0.38) | ALDH1A1TRPV4CES2CES1TAS1R3 | |
| SCHEMBL7045129 | 0.80 | ALDH1A1 (0.48) | ALDH1A1STAT3CA1CA2KDM4E | |
| SCHEMBL5360639 | 0.78 | ALDH1A1 (0.37) | ALDH1A1ALOX15TRPV4TAS1R3TAS1R1 | |
| SCHEMBL809118 | 0.76 | TRPV4 (0.50) | TRPV4CES2CES1STAT3CA1 | |
| SCHEMBL3552211 | 0.75 | STAT3 (0.56) | ALDH1A1ALOX15STAT3KDM4E | |
| SCHEMBL345016 | 0.74 | ALDH1A1 (0.48) | ALDH1A1ALOX15CES2CES1CA1 | |
| SCHEMBL8006776 | 0.73 | TRPV4 (0.47) | ALDH1A1ALOX15TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268248-B2 | Bichlorinated compounds formed under with carboxy groupand elimation of water | BAYER AKTIENGESELLSCHAFT (DE) | 2007-09-11 | — | — | US | claimed |
| US-20040167350-A1 | Bichlorinated compounds formed under with carboxy groupand elimation of water | MARHOLD ALBRECHT (DE) | 2004-08-26 | — | — | US | claimed |
| US-20030092929-A1 | Using halogenated xylene compound; chemical intermediate for quinolone antibiotics | MARHOLD ALBRECHT (DE) | 2003-05-15 | — | — | US | claimed |
| EP-1215202-A1 | Intermediates for the preparation of possibly substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-(4.3.0)-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives | BAYER AG (DE) | 2002-06-19 | — | — | EP | claimed |
| EP-0977729-B1 | 3-CYANO-2,4,5-TRIFLUORO-BENZOYL FLUORIDE AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF | BAYER AG (DE) | 2002-03-13 | — | — | EP | claimed |
| US-20010023300-A1 | Preparing by reacting 3-cyano-2,4-dichloro-4-fluoro-benzoyl chloride nucleophilically with a fluoridizing agent; forming 3-cyano-2,4,5-trifluoro-benzoyl chloride from title compound; intermediates to antiinfective quinolonecarboxylic acids | MARHOLD ALBRECHT (DE) | 2001-09-20 | — | — | US | claimed |
| US-6278013-B1 | AS CHEMICAL INTERMEDIATES FOR PREPARING QUINOLINECARBOXYLIC ACID DERIVATIVE ANTIBIOTICS USED IN VETERINARY MEDICINE | BAYER AKTIENGESELLSCHAFT (DE) | 2001-08-21 | — | — | US | claimed |
| EP-0977729-A1 | 3-CYANO-2,4,5-TRIFLUORO-BENZOYL FLUORIDE AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF | BAYER AG (DE) | 2000-02-09 | — | — | EP | claimed |
| WO-1998047862-A1 | 3-CYANO-2,4,5-TRIFLUORO-BENZOYL FLUORIDE AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 1998-10-29 | — | — | WO | claimed |
| CN-111377826-B | Green synthesis process of key intermediate of quinolone | 浙江本立科技股份有限公司 | 2021-03-02 | — | — | CN | disclosed |
| CN-111377826-A | Green synthesis process of key intermediate of quinolone | 浙江本立科技股份有限公司 | 2020-07-07 | — | — | CN | disclosed |
| US-7268248-B2 | Bichlorinated compounds formed under with carboxy groupand elimation of water | BAYER AKTIENGESELLSCHAFT (DE) | 2007-09-11 | — | — | US | disclosed |
| US-7268248-B2 | Bichlorinated compounds formed under with carboxy groupand elimation of water | BAYER AKTIENGESELLSCHAFT (DE) | 2007-09-11 | — | — | US | disclosed |
| US-7268248-B2 | Bichlorinated compounds formed under with carboxy groupand elimation of water | BAYER AKTIENGESELLSCHAFT (DE) | 2007-09-11 | — | — | US | disclosed |
| EP-0944385-A2 | USE OF 7-(1-AMINOMETHYL-2-OXA-7-AZA-BICYCLO 3.3.0]OCT-7-YL)-QUINOLONE CARBOXYLIC ACID AND NAPHTHYRIDONE CARBOXYLIC ACID DERIVATIVES FOR TREATING $i(HELICOBACTER PYLORI) INFECTIONS AND THE GASTRODUODENAL DISEASES ASSOCIATED THEREWITH | BAYER AG (DE) | 1999-09-29 | — | — | EP | disclosed |
| EP-0882049-A1 | POSSIBLY SUBSTITUTED 8-CYANO-1-CYCLOPROPYL-7-(2,8-DIAZABICYCLO- 4.3.0]-NONAN-8-YL)-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLIN CARBOXYLIC ACIDS AND THEIR DERIVATIVES | BAYER AG (DE) | 1998-12-09 | — | — | EP | disclosed |
| WO-1998047862-A1 | 3-CYANO-2,4,5-TRIFLUORO-BENZOYL FLUORIDE AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 1998-10-29 | — | — | WO | disclosed |
| WO-1998026779-A1 | THE USE OF 7-(2-OXA-5,8-DIAZABICYCLO[4.3.0]NON-8-YL)-QUINOLONE CARBOXYLIC ACID AND NAPHTHYRIDON CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF HELICOBACTER PYLORI INFECTIONS AND ASSOCIATED GASTRODUODENAL DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-06-25 | — | — | WO | disclosed |
| WO-1998026768-A2 | USE OF 7-(1-AMINOMETHYL-2-OXA-7-AZA-BICYCLO[3.3.0]OCT-7-YL)-QUINOLONE CARBOXYLIC ACID AND NAPHTHYRIDONE CARBOXYLIC ACID DERIVATIVES FOR TREATING HELICOBACTER PYLORI INFECTIONS AND THE GASTRODUODENAL DISEASES ASSOCIATED THEREWITH | BAYER AKTIENGESELLSCHAFT (DE) | 1998-06-25 | — | — | WO | disclosed |
| WO-1997031001-A1 | POSSIBLY SUBSTITUTED 8-CYANO-1-CYCLOPROPYL-7-(2,8-DIAZABICYCLO-[4.3.0]-NONAN-8-YL)-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLIN CARBOXYLIC ACIDS AND THEIR DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167350-A1 | Bichlorinated compounds formed under with carboxy groupand elimation of water | CLIC4, AFF4, CBR1 | ALDH1A1 407/4885ALOX15 1016/4885TRPV4 545/4885 |
| US-20010023300-A1 | Preparing by reacting 3-cyano-2,4-dichloro-4-fluoro-benzoyl chloride nucleophilically with a fluoridizing agent; forming 3-cyano-2,4,5-trifluoro-benzoyl chloride from title compound; intermediates to antiinfective quinolonecarboxylic acids | CLIC4, AFF4, CBR1 | ALDH1A1 1360/4885ALOX15 768/4885TRPV4 915/4885 |
| US-20030092929-A1 | Using halogenated xylene compound; chemical intermediate for quinolone antibiotics | CLIC4, FLI1, AFF4 | ALDH1A1 1343/4885ALOX15 2100/4885TRPV4 1962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.