Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5366736 | 0.90 | AKT1 (0.42) | SMYD3NPC1SMN1; SMN2RAB9A | |
| SCHEMBL5370713 | 0.90 | CTSL (0.42) | SMYD3LMNAMEN1KMT2A | |
| SCHEMBL5367918 | 0.89 | ALDH1A1 (0.41) | SMYD3ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL5370964 | 0.85 | KMT2A (0.46) | SMYD3MAPTNPC1RAB9AMEN1 | |
| SCHEMBL5366087 | 0.80 | HPGD (0.44) | SMYD3ALDH1A1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL5362924 | 0.73 | KMT2A (0.41) | SMYD3ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5371022 | 0.72 | KMT2A (0.49) | SMYD3MAPTNPC1RAB9AMEN1 | |
| SCHEMBL5364811 | 0.72 | MEN1 (0.42) | SMYD3ALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL25538362 | 0.67 | LMNA (0.59) | MAPK1SMN1; SMN2LMNARAB9AMEN1 | |
| SCHEMBL5364572 | 0.66 | SMYD3 (0.37) | SMYD3ALDH1A1MEN1KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |