Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 1/20 | 0.42 |
| ▸ | ADH1C | P00326 | 1/20 | 0.42 |
| ▸ | ADH1A | P07327 | 1/20 | 0.42 |
| ▸ | ADH7 | P40394 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7061205 | 0.84 | RAB9A (0.40) | KDM4ELMNARAB9ASMN1; SMN2GAA | |
| SCHEMBL5767016 | 0.83 | MMP8 (0.39) | CA12CA1KMT2AMEN1TDP1 | |
| SCHEMBL7064438 | 0.83 | CYP1A2 (0.49) | KMT2AMEN1TDP1KDM4ECYP3A4 | |
| SCHEMBL7062337 | 0.79 | FAAH (0.33) | KMT2AMEN1TDP1MAPT | |
| SCHEMBL7061210 | 0.78 | SMN1; SMN2 (0.42) | KMT2AMEN1KDM4ERAB9AHSD17B10 | |
| SCHEMBL5767231 | 0.77 | CHRM2 (0.44) | KMT2AMEN1TDP1KDM4EMAPT | |
| SCHEMBL7059655 | 0.76 | TSHR (0.41) | ATMKMT2AMEN1TDP1KDM4E | |
| SCHEMBL5767277 | 0.76 | ESR1 (0.41) | CA1CA2 | |
| SCHEMBL27968389 | 0.72 | EPHX2 (0.43) | — | |
| SCHEMBL6762362 | 0.72 | RIPK1 (0.37) | RIPK1KMT2AMEN1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253169-B2 | Aza compounds, pharmaceutical compositions and methods of use | GLIAMED, INC. (US) | 2007-08-07 | — | — | US | disclosed |
| EP-1242383-A1 | AZA COMPOUNDS HAVING NEURONAL ACTIVITY | GPI NIL Holdings, Inc. (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6417189-B1 | DRUGS WITH PYRAZOLE KETONE DERIVATIVES | GPI NIL HOLDINGS, INC. | 2002-07-09 | — | — | US | disclosed |
| US-20020028814-A1 | Aza compounds, pharmaceutical compositions and methods of use | GLIAMED, INC. | 2002-03-07 | — | — | US | disclosed |
| WO-2001079177-A1 | CYCLIC DIAZA COMPOUNDS FOR TREATING NEURODEGENERATIVE DISORDERS | GPI NIL HOLDINGS, INC. (US) | 2001-10-25 | — | — | WO | disclosed |
| WO-2001036388-A1 | AZA COMPOUNDS HAVING NEURONAL ACTIVITY | GPI NIL HOLDINGS, INC. (US) | 2001-05-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028814-A1 | Aza compounds, pharmaceutical compositions and methods of use | GRIN3A, CHRNA5, GRIN3B | ADH1B 818/4885ADH1C 1352/4885ADH1A 1375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.