Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5373022 | 0.77 | ADH1B (0.42) | MAPTLMNAKMT2AMEN1KDM4E | |
| SCHEMBL7061210 | 0.71 | SMN1; SMN2 (0.42) | CHRM2L3MBTL1ALDH1A1KMT2AMEN1 | |
| SCHEMBL513576 | 0.70 | CHRM2 (0.57) | CHRM2L3MBTL1MAPTALDH1A1LMNA | |
| SCHEMBL7059655 | 0.69 | TSHR (0.41) | CHRM2L3MBTL1MAPTALDH1A1LMNA | |
| SCHEMBL7061205 | 0.69 | RAB9A (0.40) | L3MBTL1ALDH1A1LMNAKDM4EGAA | |
| SCHEMBL10245653 | 0.68 | CHRM2 (0.54) | CHRM2L3MBTL1MAPTALDH1A1LMNA | |
| SCHEMBL5767016 | 0.68 | MMP8 (0.39) | L3MBTL1MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL4477248 | 0.68 | KCNA5 (0.49) | CHRM2L3MBTL1MAPTALDH1A1LMNA | |
| SCHEMBL7062957 | 0.68 | CYP2A6 (0.50) | KMT2AMEN1 | |
| SCHEMBL7064438 | 0.68 | CYP1A2 (0.49) | CHRM2MAPTALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244660-B1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| US-20030181449-A1 | Methods and compositions for the treatment of pain | ASTRAZENCA AB (SE) | 2003-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181449-A1 | Methods and compositions for the treatment of pain | OPRK1, ACHE, OPRD1 | CHRM2 69/4885L3MBTL1 2331/4885MAPT 2472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.