Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5373022 | 0.83 | ADH1B (0.42) | CA1CA2CA12CYP3A4TDP1 | |
| SCHEMBL7061205 | 0.81 | RAB9A (0.40) | ALDH1A1KDM4EHTTL3MBTL1RAB9A | |
| SCHEMBL7062337 | 0.75 | FAAH (0.33) | ALDH1A1TSHRTDP1HTTMAPT | |
| SCHEMBL5767277 | 0.75 | ESR1 (0.41) | CA1CA2 | |
| SCHEMBL7064438 | 0.73 | CYP1A2 (0.49) | ALDH1A1CYP3A4TDP1KDM4EHTT | |
| SCHEMBL7059655 | 0.70 | TSHR (0.41) | ALDH1A1MAPK1TSHRTDP1KDM4E | |
| SCHEMBL30945860 | 0.69 | ALDH1A1 (0.61) | MMP8CA1CA2CA9CA12 | |
| SCHEMBL3306932 | 0.69 | ADH1B (0.55) | MMP8CA1CA2CA9CA12 | |
| SCHEMBL6762362 | 0.69 | RIPK1 (0.37) | ALDH1A1KDM4EHPGDSMN1; SMN2MEN1 | |
| SCHEMBL7061210 | 0.69 | SMN1; SMN2 (0.42) | ALDH1A1KDM4EL3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244660-B1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| US-20030181449-A1 | Methods and compositions for the treatment of pain | ASTRAZENCA AB (SE) | 2003-09-25 | — | — | US | disclosed |
| EP-1244660-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047924-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2001-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181449-A1 | Methods and compositions for the treatment of pain | OPRK1, ACHE, OPRD1 | MMP8 254/4885CA1 590/4885CA2 1098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.