SCHEMBL537374

SCHEMBL537374

O=Cc1ccc(C(F)(F)F)cc1O

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.56
MAPT P10636 1/20 0.56
TYR P14679 2/20 0.47
TRIM24 O15164 2/20 0.47
TRIM33 Q9UPN9 2/20 0.47
KDM4E B2RXH2 1/20 0.46
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
NQO2 P16083 1/20 0.42
CES2 O00748 2/20 0.40
PIK3CD O00329 1/20 0.40
PIK3CA P42336 1/20 0.40
PIK3CB P42338 1/20 0.40
PIK3CG P48736 1/20 0.40
PRKDC P78527 1/20 0.40
ERN1 O75460 4/20 0.40
PTGS1 P23219 1/20 0.39
CDK5 Q00535 1/20 0.38
CDK5R1 Q15078 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL248602 0.84 ERN1 (0.52) POLBMAPTTRIM24TRIM33MEN1
SCHEMBL5737735 0.81 MAPT (0.58) POLBMAPTERN1
SCHEMBL6853258 0.81 POLB (0.42) POLBMAPTKDM4EMEN1KMT2A
SCHEMBL1527058 0.80 ALDH1A1 (0.57) POLBMAPTTYRTRIM24TRIM33
SCHEMBL5643460 0.78 TYR (0.50) POLBMAPTTYRTRIM24TRIM33
SCHEMBL153434 0.78 CYP1A1 (0.44) POLBMAPTKDM4EMEN1KMT2A
SCHEMBL3033291 0.78 CYP1A1 (0.46) POLBMAPTKDM4ECES2
SCHEMBL472401 0.78 CES2 (0.50) POLBMAPTKDM4ECES2ERN1
SCHEMBL7254716 0.78 POLB (0.43) POLBMAPTKDM4ECES2
SCHEMBL21823799 0.77 KDM4E (0.43) POLBMAPTKDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 261 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119661416-A Small molecular probe and preparation method and application thereof 上海师范大学 2025-03-21 CN claimed
CN-119639391-A High-viscosity waterproof polyacrylate emulsion pressure-sensitive adhesive and preparation method and application thereof 山东佳润新材料有限公司 2025-03-18 CN claimed
CN-122080106-A Oleanolic acid acylhydrazone derivative and preparation method and application thereof 2026-05-26 CN disclosed
WO-2026090589-A1 HETEROCYCLIC HBS1L DEGRADERS TANGO THERAPEUTICS, INC. (US) 2026-04-30 WO disclosed
US-20260092045-A1 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2026-04-02 US disclosed
US-20250388585-A1 PRMT5 INHIBITORS AND USES THEREOF GILEAD SCIENCES INC (US) 2025-12-25 US disclosed
US-20250382303-A1 NOVEL COMPOUND AS NADPH OXIDASE 2 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING SAME DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) 2025-12-18 US disclosed
EP-4635568-A2 COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES ACADIA Pharmaceuticals Inc. (US) 2025-10-22 EP disclosed
US-12448388-B2 PRMT5 inhibitors and uses thereof GILEAD SCIENCES, INC. (US) 2025-10-21 US disclosed
US-20250275991-A1 ORAL COMPLEMENT FACTOR D INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2025-09-04 US disclosed
EP-3672954-B1 COMPOUNDS, SALTS THEREOF AND THEIR USE FOR THE TREATMENT OF DISEASES ACADIA PHARM INC (US) 2025-08-13 EP disclosed
US-5474998-A Pesticides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1995-12-12 US disclosed
EP-0543930-A1 ARTHROPODICIDAL PYRAZOLINES, PYRAZOLIDINES AND HYDRAZINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-06-02 EP disclosed
WO-1992003421-A2 ARTHROPODICIDAL PYRAZOLINES, PYRAZOLIDINES AND HYDRAZINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-03-05 WO disclosed
EP-0463090-A1 ARTHROPODICIDAL TETRAHYDROBENZOPYRANOPYRAZOLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-01-02 EP disclosed
WO-1990010623-A2 ARTHROPODICIDAL TETRAHYDROBENZOPYRANOPYRAZOLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1990-09-20 WO disclosed
CN-1045393-A The tetrahydro benzo pyrans and the pyrazoles of Arthropodicidal DU PONT (US) 1990-09-19 CN disclosed
EP-0386892-A2 Arthropodicidal tetrahydrobenzopyranopyrazoles E.I. DU PONT DE NEMOURS AND COMPANY (US) 1990-09-12 EP disclosed
US-3944674-A Combating insects with o dimethoxymethylphenyl-N-methylcarbamate CIBA-GEIGY AG (CH) 1976-03-16 US disclosed
US-3933858-A INSECTICIDES CIBA-GEIGY AG (CH) 1976-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250388585-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT1, PRMT5, PRMT6 POLB 716/4885MAPT 3947/4885TYR 4680/4885
US-20250275991-A1 ORAL COMPLEMENT FACTOR D INHIBITORS CFD, CFH, CFB POLB 2308/4885MAPT 3671/4885TYR 1946/4885
US-12448388-B2 PRMT5 inhibitors and uses thereof PRMT5, PRMT1, PRMT9 POLB 826/4885MAPT 2217/4885TYR 4194/4885
US-20260092045-A1 SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS TFPI, F3, BTK POLB 4835/4885MAPT 263/4885TYR 44/4885
US-20250382303-A1 NOVEL COMPOUND AS NADPH OXIDASE 2 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING SAME CYBB, NOX4, NOX1 POLB 2024/4885MAPT 202/4885TYR 300/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.