SCHEMBL537590

SCHEMBL537590

CCc1cccc2[nH]c(C=Cc3cc(N)ccc3Cl)nc12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 7/20 0.39
▸ RAB9A P51151 7/20 0.39
▸ MEN1 O00255 7/20 0.39
▸ KMT2A Q03164 7/20 0.39
▸ NPC1 O15118 6/20 0.39
▸ GAA P10253 6/20 0.39
▸ LMNA P02545 5/20 0.39
▸ HTT P42858 5/20 0.39
▸ ALDH1A1 P00352 4/20 0.39
▸ HPGD P15428 4/20 0.39
▸ SMN1; SMN2 Q16637 4/20 0.39
▸ KDM4E B2RXH2 3/20 0.39
▸ GLA P06280 2/20 0.39
▸ PKM P14618 2/20 0.39
▸ ALPL P05186 1/20 0.39
▸ ALPG P10696 1/20 0.39
▸ NFKB1 P19838 1/20 0.36
▸ RECQL P46063 1/20 0.36
▸ NFKB2 Q00653 1/20 0.36
▸ RELA Q04206 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17609264 0.86 MAPT (0.40) MAPTRAB9AMEN1KMT2ANPC1
SCHEMBL537589 0.82 RAB9A (0.41) MAPTRAB9AMEN1KMT2ANPC1
SCHEMBL17609266 0.77 NPC1 (0.65) MAPTRAB9AMEN1KMT2ANPC1
SCHEMBL17609165 0.72 RIPK1 (0.47) MAPTRAB9AMEN1KMT2ANPC1
SCHEMBL18631865 0.70 RAB9A (0.41) MAPTRAB9AMEN1KMT2ANPC1
SCHEMBL8818596 0.68 NUDT1 (0.47) MEN1KMT2AALDH1A1ATP4AATP4B
SCHEMBL8548085 0.68 GAA (0.55) MAPTRAB9AMEN1KMT2ANPC1
SCHEMBL282088 0.64 CYP3A4 (0.52) MAPTRAB9AMEN1KMT2ANPC1
SCHEMBL17609158 0.64 RAB9A (0.43) MAPTRAB9AMEN1KMT2ANPC1
SCHEMBL6117500 0.64 RAB9A (0.43) MAPTRAB9AMEN1KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3091014-A1 FLUORESCENT CELLULAR MARKERS Zayas, Beatriz (US) 2016-11-09 — — EP disclosed
US-8124770-B2 Fluorescent cellular markers NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2012-02-28 — — US disclosed
EP-2414355-A2 FLUORESCENT CELLULAR MARKERS Zayas, Beatriz (US) 2012-02-08 — — EP disclosed
WO-2010135751-A2 FLUORESCENT CELLULAR MARKERS BEATRIZ ZAYAS BEATRIZ (US) 2010-11-25 — — WO disclosed
US-20100256378-A1 FLUORESCENT CELLULAR MARKERS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-10-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256378-A1 FLUORESCENT CELLULAR MARKERS AIFM1, CASP3, BAX MAPT 3510/4885RAB9A 862/4885MEN1 2951/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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