Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 4/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | ASPH | Q12797 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.34 |
| ▸ | EIF4E | P06730 | 1/20 | 0.34 |
| ▸ | PTPRB | P23467 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | BAD | Q92934 | 1/20 | 0.34 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5307870 | 0.88 | ASPH (0.43) | KMOKDM4EALDH1A1SCDASPH | |
| SCHEMBL5307717 | 0.83 | ASPH (0.45) | KMOKIF11ASPHBCL2L1BAD | |
| SCHEMBL5315830 | 0.77 | ASPH (0.48) | KMOASPH | |
| SCHEMBL5313162 | 0.74 | CNR2 (0.48) | KMOSCDASPH | |
| SCHEMBL28021530 | 0.72 | CES2 (0.50) | ALDH1A1KIF11 | |
| SCHEMBL5339306 | 0.71 | SCD (0.41) | NPC1ALDH1A1SCDSTING1 | |
| SCHEMBL5312928 | 0.71 | SCD (0.50) | SCD | |
| SCHEMBL29406303 | 0.70 | KEAP1 (0.55) | KDM4EALDH1A1ASPH | |
| SCHEMBL222474 | 0.70 | KEAP1 (0.55) | KDM4EALDH1A1ASPH | |
| SCHEMBL5310364 | 0.68 | CNR2 (0.47) | KMOASPH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044085-A2 | HETEROARYL COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2007-04-19 | — | — | WO | disclosed |