Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | GLA | P06280 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL244868 | 0.77 | KMT2A (0.59) | ALDH1A1GLAHPGDMAPTACHE | |
| SCHEMBL29911341 | 0.77 | KMT2A (0.59) | ALDH1A1GLAHPGDMAPTACHE | |
| SCHEMBL2172354 | 0.77 | ALDH1A1 (0.56) | ALDH1A1GLAHPGDMAPTACHE | |
| SCHEMBL31278632 | 0.76 | KMT2A (0.57) | ALDH1A1GLAHPGDMAPTACHE | |
| SCHEMBL28217575 | 0.75 | ALDH1A1 (0.48) | ALDH1A1GLAHPGDMAPTACHE | |
| SCHEMBL3300463 | 0.74 | TLR8 (0.53) | ALDH1A1GLAHPGDMAPTACHE | |
| SCHEMBL538053 | 0.74 | ALDH1A1 (0.59) | ALDH1A1GLAHPGDMAPTACHE | |
| SCHEMBL17274766 | 0.74 | ALDH1A1 (0.52) | ALDH1A1GLAHPGDMAPTACHE | |
| SCHEMBL8400543 | 0.74 | ALDH1A1 (0.52) | ALDH1A1GLAHPGDMAPTACHE | |
| SCHEMBL538070 | 0.74 | KMT2A (0.55) | ALDH1A1GLAHPGDMAPTACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641341-B1 | METHOD FOR PREPARING BENZO [b]NAPHTHYRIDINES | RHONE POULENC RORER SA (FR) | 2000-03-01 | — | — | EP | claimed |
| US-5484921-A | Process for preparing benzo[b]naphthyridines | LABORATOIRE ROGER BELLON (FR) | 1996-01-16 | — | — | US | claimed |
| US-8598159-B2 | Therapeutic pyrazoloquinoline derivatives | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2013-12-03 | — | — | US | disclosed |
| EP-2166852-B1 | THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES | HELICON THERAPEUTICS INC (US) | 2012-02-08 | — | — | EP | disclosed |
| US-20110065693-A1 | THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES | HELICON THERAPEUTICS, INC. (US) | 2011-03-17 | — | — | US | disclosed |
| US-7872002-B2 | Therapeutic pyrazoloquinoline derivatives | HELICON THERAPEUTICS, INC. (US) | 2011-01-18 | — | — | US | disclosed |
| CN-101742908-A | therapeutic pyrazoloquinoline derivatives | HELICON THERAPEUTICS INC | 2010-06-16 | — | — | CN | disclosed |
| EP-2166852-A1 | THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES | Helicon Therapeutics, Inc. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154438-A1 | THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES | HELICON THERAPEUTICS, INC. (US) | 2008-12-18 | — | — | WO | disclosed |
| US-20080306049-A1 | THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES | HELICON THERAPEUTICS, INC. (US) | 2008-12-11 | — | — | US | disclosed |
| EP-0861864-B1 | Method of preparation of polyquinolines | HITACHI CHEMICAL CO LTD (JP) | 2004-08-25 | — | — | EP | disclosed |
| US-5786071-A | Method of preparation of polyquinolines | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1998-07-28 | — | — | US | disclosed |
| US-5723573-A | ACETYLENIC END GROUPS | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1998-03-03 | — | — | US | disclosed |
| US-5648448-A | Method of preparation of polyquinolines | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1997-07-15 | — | — | US | disclosed |
| US-5484921-A | Process for preparing benzo[b]naphthyridines | LABORATOIRE ROGER BELLON (FR) | 1996-01-16 | — | — | US | disclosed |
| US-5484921-A | Process for preparing benzo[b]naphthyridines | LABORATOIRE ROGER BELLON (FR) | 1996-01-16 | — | — | US | disclosed |
| US-5442070-A | Derivatives of fluoro-quinoline carboxylic-3-acid and preparation therefor | LABORATOIRE ROGER BELLON (FR) | 1995-08-15 | — | — | US | disclosed |
| EP-0641341-A1 | METHOD FOR PREPARING BENZO b]NAPHTHYRIDINES | LABORATOIRE ROGER BELLON (FR) | 1995-03-08 | — | — | EP | disclosed |
| EP-0538101-A1 | Process for the preparation of benzo(b)naphthyridines | LABORATOIRE ROGER BELLON (FR) | 1993-04-21 | — | — | EP | disclosed |
| WO-1993007145-A1 | METHOD FOR PREPARING BENZO[b]NAPHTHYRIDINES | LABORATOIRE ROGER BELLON (FR) | 1993-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306049-A1 | THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES | GABRA5, GABRB1, GABRB2 | ALDH1A1 587/4885GLA 4673/4885HPGD 1684/4885 |
| US-20110065693-A1 | THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES | GABRA5, GABRB1, GABRB2 | ALDH1A1 587/4885GLA 4673/4885HPGD 1684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.