SCHEMBL540323

SCHEMBL540323

CC(C)OC(=O)C(C#N)=CC(=O)CO

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
MAPT P10636 2/20 0.39
PTP4A3 O75365 1/20 0.39
PTP4A2 Q12974 1/20 0.39
PTP4A1 Q93096 1/20 0.39
LMNA P02545 1/20 0.38
TP53 P04637 3/20 0.36
HPGD P15428 2/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CYP2C9 P11712 1/20 0.33
RAB9A P51151 1/20 0.30
TSHR P16473 1/20 0.30
IDE P14735 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1985141 0.80 ALDH1A1 (0.44) ALDH1A1MAPTPTP4A1LMNATP53
SCHEMBL27853457 0.79 ALDH1A1 (0.50) ALDH1A1MAPTPTP4A3PTP4A2PTP4A1
SCHEMBL21037252 0.79 ALDH1A1 (0.50) ALDH1A1MAPTPTP4A3PTP4A2PTP4A1
SCHEMBL540781 0.77 CYP2C9 (0.57) ALDH1A1MAPTPTP4A1LMNATP53
SCHEMBL27530922 0.75 ALDH1A1 (0.44) ALDH1A1MAPTPTP4A3PTP4A2PTP4A1
SCHEMBL2230964 0.75 CYP2C9 (0.42) ALDH1A1MAPTPTP4A1LMNATP53
SCHEMBL24089780 0.74 ALDH1A1 (0.47) ALDH1A1MAPTPTP4A3PTP4A2PTP4A1
SCHEMBL667301 0.73 ALDH1A1 (0.46) ALDH1A1MAPTPTP4A3PTP4A2PTP4A1
SCHEMBL11653026 0.73 ALDH1A1 (0.46) ALDH1A1MAPTPTP4A3PTP4A2PTP4A1
SCHEMBL11651547 0.72 ALDH1A1 (0.43) ALDH1A1MAPTPTP4A3PTP4A2PTP4A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200315624-A1 Flexible Material Dispenser ETHICON INC (US) 2020-10-08 US claimed
EP-3513744-A1 MESH DISPENSER Ethicon, Inc. (US) 2019-07-24 EP claimed
EP-2515954-A1 OXIDIZED REGENERATED CELLULOSE ADHESIVE TAPE Advanced Technologies and Regenerative Medicine, LLC (US) 2012-10-31 EP claimed
WO-2011087722-A1 OXIDIZED REGENERATED CELLULOSE ADHESIVE TAPE ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC (US) 2011-07-21 WO claimed
US-20110152924-A1 OXIDIZED REGENERATED CELLULOSE ADHESIVE TAPE ADVANCED TECHNOLOGIES AND REGENERATIVE MEDICINE, LLC 2011-06-23 US claimed
US-7932305-B2 Viscous α-cyanoacrylate compositions ETHICON, INC. (US) 2011-04-26 US claimed
EP-2152172-A1 MESH DISPENSER Closure Medical Corporation (US) 2010-02-17 EP claimed
US-20090326095-A1 Viscous alpha-Cyanoacrylate Compositions ETHICON, INC. 2009-12-31 US claimed
WO-2009158302-A2 VISCOUS ALPHA-CYANOACRYLATE COMPOSITIONS CLOSURE MEDICAL CORPORATION (US) 2009-12-30 WO claimed
EP-1317294-B2 ABSORBABLE ADHESIVE COMPOSITIONS CLOSURE MEDICAL CORP (US) 2009-09-02 EP claimed
WO-2008154375-A1 MESH DISPENSER CLOSURE MEDICAL CORPORATION (US) 2008-12-18 WO claimed
US-20080302487-A1 MESH DISPENSER CLOSURE MEDICAL CORPORATION (US) 2008-12-11 US claimed
US-20080241249-A1 Cyanoacrylate composite CLOSURE MEDICAL CORPORATION (US) 2008-10-02 US claimed
EP-1928920-A2 IMPROVED STABILIZER CYANOACRYLATE FORMULATIONS Closure Medical Corporation (US) 2008-06-11 EP claimed
WO-2007041143-A2 IMPROVED STABILIZER CYANOACRYLATE FORMULATIONS CLOSURE MEDICAL CORPORATION (US) 2007-04-12 WO claimed
US-20070078207-A1 Stabilizer cyanoacrylate formulations ETHICON, INC. 2007-04-05 US claimed
EP-1317294-B1 ABSORBABLE ADHESIVE COMPOSITIONS CLOSURE MEDICAL CORP (US) 2005-03-16 EP claimed
EP-1317294-A1 ABSORBABLE ADHESIVE COMPOSITIONS Closure Medical Corporation (US) 2003-06-11 EP claimed
US-20020037310-A1 Absorbable adhesive compositions CLOSURE MEDICAL CORPORATION (US) 2002-03-28 US claimed
WO-2002009785-A1 ABSORBABLE ADHESIVE COMPOSITIONS CLOSURE MEDICAL CORPORATION (US) 2002-02-07 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080241249-A1 Cyanoacrylate composite ALOX5, SCD, SCD5 ALDH1A1 806/4885MAPT 1601/4885PTP4A3 2475/4885
US-20020037310-A1 Absorbable adhesive compositions EPCAM, CDH1, ICAM1 ALDH1A1 178/4885MAPT 2104/4885PTP4A3 4597/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.