Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 3/20 | 0.37 |
| ▸ | MMP9 | P14780 | 3/20 | 0.37 |
| ▸ | MMP13 | P45452 | 3/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5466341 | 0.90 | LMNA (0.39) | GAAKMT2APOLBALDH1A1TSHR | |
| SCHEMBL5343117 | 0.72 | ALDH1A1 (0.41) | GAAKMT2APOLBALDH1A1TSHR | |
| SCHEMBL5374543 | 0.71 | POLB (0.43) | GAAKMT2APOLBALDH1A1TSHR | |
| SCHEMBL5716889 | 0.71 | LMNA (0.47) | KMT2APOLBALDH1A1TSHRHSD17B10 | |
| SCHEMBL5716963 | 0.70 | LMNA (0.50) | KMT2APOLBALDH1A1TP53MAPT | |
| SCHEMBL5317926 | 0.69 | CXCR2 (0.47) | KMT2APOLBALDH1A1MAPTHTT | |
| SCHEMBL4903613 | 0.69 | TP53 (0.48) | KMT2AALDH1A1TSHRTP53MAPT | |
| SCHEMBL4904034 | 0.68 | LMNA (0.50) | KMT2APOLBALDH1A1TSHRTP53 | |
| SCHEMBL5373887 | 0.67 | POLB (0.49) | GAAKMT2APOLBALDH1A1TSHR | |
| SCHEMBL4904032 | 0.67 | KEAP1 (0.49) | KMT2AALDH1A1TSHRMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007091140-A1 | SUBSTITUTED PHENYLSULFAMOYL COMPOUNDS AS PPAR AGONISTS | PFIZER PRODUCTS INC. (US) | 2007-08-16 | — | — | WO | disclosed |