Sugi Predict

Sugi Predict / Compounds / SCHEMBL5407633

SCHEMBL5407633

SCHEMBL5407633

CCSc1n[nH]c(=O)n1OC

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ ALDH1A1 P00352 8/20 0.33
▸ LMNA P02545 2/20 0.33
▸ POLB P06746 1/20 0.33
▸ MAPK1 P28482 2/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ MAPT P10636 3/20 0.32
▸ HTT P42858 2/20 0.32
▸ TLR8 Q9NR97 1/20 0.32
▸ HPGD P15428 2/20 0.31
▸ KDM4E B2RXH2 1/20 0.31
▸ HSD17B10 Q99714 1/20 0.31
▸ RAB9A P51151 1/20 0.30
▸ ATM Q13315 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8814240 0.86 LMNA (0.40) MEN1KMT2AALDH1A1LMNAPOLB
SCHEMBL8810931 0.79 TLR8 (0.41) MAPTTLR8KDM4E
SCHEMBL9414036 0.76 ALDH1A1 (0.42) MEN1KMT2AALDH1A1LMNAPOLB
SCHEMBL3525757 0.74 LMNA (0.43) MEN1KMT2AALDH1A1LMNAPOLB
SCHEMBL9593492 0.74 MAPT (0.41) MEN1KMT2AALDH1A1LMNAPOLB
SCHEMBL14505450 0.74 TLR8 (0.31) MEN1KMT2AALDH1A1LMNAPOLB
SCHEMBL3934691 0.72 MTNR1B (0.32) —
SCHEMBL8801439 0.69 MAT2A (0.31) LMNA
SCHEMBL14505567 0.69 ALDH1A1 (0.34) ALDH1A1POLBMAPK1SMN1; SMN2HTT
SCHEMBL8621897 0.69 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE39607-E1 Herbicidal sulphonylamino(thio) carbonyl compounds BAYER AKTIENGESELLSCHAFT (DE) 2007-05-01 — — US disclosed
US-20040157744-A1 Substituted fluoroalkoxyphenylsulfonyl-amino(thio)carbonyltriazolino(thi)ones BAYER CROPSCIENCE AG (DE) 2004-08-12 — — US disclosed
US-6686478-B2 NOVEL INTERMEDIATES FOR THEIR PREPARATION; HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 2004-02-03 — — US disclosed
EP-1379512-A1 SUBSTITUTED FLUORALKOXYPHENYLSULFONYLAMINO(THIO)CARBONYLTRIAZOLINO(THI)ONES Bayer CropScience AG (DE) 2004-01-14 — — EP disclosed
US-6677277-B1 Substituted sulphonyl amino(thio)carbonyl compounds and their use as herbicides BAYER AKTIENGESELLSCHAFT (DE) 2004-01-13 — — US disclosed
EP-1344771-A1 2-alkoxy-phenylsulphonic acid derivatives as intermediates for herbicidal sulphonylamino(thio)carbonyl compounds Bayer CropScience AG (DE) 2003-09-17 — — EP disclosed
EP-0906293-B1 SUBSTITUTED SULPHONYL AMINO(THIO)CARBONYL COMPOUNDS AND THEIR USE AS HERBICIDES BAYER CROPSCIENCE AG (DE) 2003-09-17 — — EP disclosed
US-20030171595-A1 Thienylsulphonylamino(thio)carbonyl compounds MULLER KLAUS-HELMUT (DE) 2003-09-11 — — US disclosed
US-20030162979-A1 Substituted sulphonylamino(thio)carbonyl compounds MULLER KLAUS-HELMUT (DE) 2003-08-28 — — US disclosed
EP-0842157-B1 HERBICIDAL SULPHONYLAMINO(THIO)CARBONYL COMPOUNDS BAYER CROPSCIENCE AG (DE) 2003-08-27 — — EP disclosed
US-5750718-A CHEMICAL INTERMEDIATES BAYER AKTIENGESELLSCHAFT (DE) 1998-05-12 — — US disclosed
WO-1998007721-A1 5,6-DIHYDRO-[1,4,2]-DIOXAZIN-SUBSTITUTED (HETERO)ARYL-(OXY-,IMINO-, ALKYL-)-SULPHONYLAMINO(THIO)CARBONYL-HETEROCYCLYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1998-02-26 — — WO disclosed
WO-1997016449-A1 SUBSTITUTED SULPHONYLAMINO (THIO)CARBONYL COMPOUNDS AS HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-05-09 — — WO disclosed
US-5599944-A Intermediates for herbicidal sulphonylaminocarbonyltriazolinones having substituents which are bonded via sulphur BAYER AKTIENGESELLSCHAFT (DE) 1997-02-04 — — US disclosed
WO-1997003056-A1 HERBICIDAL SULPHONYLAMINO(THIO)CARBONYL COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 1997-01-30 — — WO disclosed
US-5380863-A Herbicidal sulphonylaminocarbonyltriazolinones having substituents which are bonded via sulphur BAYER AKTIENGESELLSCHAFT (DE) 1995-01-10 — — US disclosed
US-5276162-A Herbicidal sulphonylaminocarbonyltriazolinones having substituents which are bonded via sulphur BAYER AKTIENGESELLSCHAFT (DE) 1994-01-04 — — US disclosed
US-5149356-A Herbicidal sulphonylaminocarbonyltriazolinones having substituents which are bonded via sulphur BAYER AKTIENGESELLSCHAFT (DE) 1992-09-22 — — US disclosed
US-5085684-A Herbicidal sulphonylaminocarbonyltriazolinones having substituents which are bonded via sulphur BAYER AKTIENGESELLSCHAFT (DE) 1992-02-04 — — US disclosed
EP-0431291-A2 Sulfonylaminocarbony-triazolinones having substituents attached through sulfur BAYER AG (DE) 1991-06-12 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030171595-A1 Thienylsulphonylamino(thio)carbonyl compounds CBR3, CBR1, QSOX1 MEN1 3843/4885KMT2A 2753/4885ALDH1A1 89/4885
US-20030162979-A1 Substituted sulphonylamino(thio)carbonyl compounds CBR3, CTH, CBR1 MEN1 4546/4885KMT2A 2161/4885ALDH1A1 261/4885
US-20040157744-A1 Substituted fluoroalkoxyphenylsulfonyl-amino(thio)carbonyltriazolino(thi)ones ROS1, RIF1, NAT1 MEN1 2487/4885KMT2A 597/4885ALDH1A1 278/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.