SCHEMBL541064

SCHEMBL541064

CCOCCOC(N)C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.45
TSHR P16473 1/20 0.45
THRB P10828 1/20 0.39
SLC1A3 P43003 3/20 0.33
SLC1A2 P43004 3/20 0.33
SLC1A1 P43005 3/20 0.33
NOS3 P29474 2/20 0.33
NOS1 P29475 2/20 0.33
NOS2 P35228 2/20 0.33
GRIK1 P39086 2/20 0.32
GABRP O00591 2/20 0.32
GABRD O14764 2/20 0.32
GABRA1 P14867 2/20 0.32
GABRB1 P18505 2/20 0.32
GABRG2 P18507 2/20 0.32
GABRB3 P28472 2/20 0.32
GABRA5 P31644 2/20 0.32
GABRA3 P34903 2/20 0.32
GABRA2 P47869 2/20 0.32
GABRB2 P47870 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL788324 0.98 ALDH1A1 (0.43) ALDH1A1TSHRTHRBSLC1A3SLC1A2
SCHEMBL19852653 0.82 ALDH1A1 (0.41) ALDH1A1TSHRTHRB
SCHEMBL303947 0.79
SCHEMBL780052 0.78 ALDH1A1 (0.45) ALDH1A1TSHRTHRB
SCHEMBL1172448 0.78 ALDH1A1 (0.45) ALDH1A1TSHRTHRB
SCHEMBL10808653 0.78 ALDH1A1 (0.45) ALDH1A1TSHRTHRB
SCHEMBL2329737 0.77 ALDH1A1 (0.43) ALDH1A1TSHRTHRBNOS3NOS1
SCHEMBL6363592 0.77 ALDH1A1 (0.43) ALDH1A1TSHRTHRB
SCHEMBL30065241 0.77 ALDH1A1 (0.43) ALDH1A1TSHRTHRB
SCHEMBL16246663 0.77 ALDH1A1 (0.43) ALDH1A1TSHRTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170283830-A1 COMPOSITIONS FOR ENHANCING TARGETED GENE EDITING AND METHODS OF USE THEREOF NATIONAL SCIENCE FOUNDATION 2017-10-05 US claimed
WO-2016207779-A1 IMMUNOGENIC SYNTHETIC OLIGOPEPTIDES STRELNIKOV, Evgeny (RU) 2016-12-29 WO claimed
WO-2016207782-A1 IMMUNOGENIC SYNTHETIC OLIGOPEPTIDES FOR A VACCINE AGAINST HIV STRELNIKOV, Evgeny (RU) 2016-12-29 WO claimed
WO-2016207781-A1 IMMUNOGENIC SYNTHETIC OLIGOPEPTIDES FOR A VACCINE AGAINST MYCOBACTERIUM TUBERCULOSIS STRELNIKOV, Evgeny (RU) 2016-12-29 WO claimed
EP-3108896-A1 IMMUNOGENIC SYNTHETIC OLIGOPEPTIDES Spinosa, Jean-Pierre (CH) 2016-12-28 EP claimed
WO-2010123983-A1 COMPOSTIONS AND METHODS FOR TARGETED GENE THERAPY YALE UNIVERSITY (US) 2010-10-28 WO claimed
US-20260021194-A1 ANTIBODY DRUG CONJUGATE (ADC) TARGETING NECTIN 4 AND COMPRISING AN EXATECAN PAYLOAD LILLY CO ELI (US) 2026-01-22 US disclosed
US-20250332277-A1 PROTEIN TYROSINE KINASE 7 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES LILLY CO ELI (US) 2025-10-30 US disclosed
WO-2025227010-A1 PROTEIN TYROSINE KINASE 7 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES ELI LILLY AND COMPANY (US) 2025-10-30 WO disclosed
US-12419964-B2 Antibody drug conjugate (ADC) targeting Nectin 4 and comprising an exatecan payload ELI LILLY AND COMPANY (US) 2025-09-23 US disclosed
US-20250127916-A1 ANTIBODY DRUG CONJUGATE (ADC) TARGETING NECTIN 4 AND COMPRISING AN EXATECAN PAYLOAD ELI LILLY AND COMPANY 2025-04-24 US disclosed
US-20250122239-A1 DUAL AGONIST GLP-1 AND NEUROTENSIN FUSION PEPTIDE HOLST BIRGITTE (DK) 2025-04-17 US disclosed
WO-2025073812-A1 ANTIBODY DRUG CONJUGATE (ADC) TARGETING NECTIN 4 AND COMPRISING AN EXATECAN PAYLOAD ELI LILLY AND COMPANY (DE) 2025-04-10 WO disclosed
EP-1904079-A2 PEPTIDE NUCLEIC ACID PROBES FOR ANALYSIS OF MICROORGANISMS AdvanDx, Inc. (US) 2008-04-02 EP disclosed
WO-2007081792-A2 METHODS AND COMPOSITIONS RELATED TO IMPROVING PROPERTIES OF PHARMACOLOGICAL AGENTS TARGETING NERVOUS SYSTEM UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2007-07-19 WO disclosed
WO-2006130872-A2 PEPTIDE NUCLEIC ACID PROBES FOR ANALYSIS OF MICROORGANISMS ADVANDX, INC. (US) 2006-12-07 WO disclosed
US-7060432-B1 contacting a yeast sample with yeast specific enzyme-linked probes, hybridizes to form probe/target sequence within; for analysis of beer and liquor APPLERA CORPORATION (US) 2006-06-13 US disclosed
US-20050054836-A1 Chimeric molecules to modulate gene expression COLD SPRING HARBOR LABORATORY 2005-03-10 US disclosed
EP-1416972-A2 CHIMERIC MOLECULES TO MODULATE GENE EXPRESSION COLD SPRING HARBOR LABORATORY (US) 2004-05-12 EP disclosed
WO-2002038738-A2 CHIMERIC MOLECULES TO MODULATE GENE EXPRESSION COLD SPRING HARBOR LABORATORY (US) 2002-05-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12419964-B2 Antibody drug conjugate (ADC) targeting Nectin 4 and comprising an exatecan payload NECTIN4, SDC4, EPCAM ALDH1A1 1777/4885TSHR 1104/4885THRB 2649/4885
US-20170283830-A1 COMPOSITIONS FOR ENHANCING TARGETED GENE EDITING AND METHODS OF USE THEREOF ZFX, ATR, CHEK1 ALDH1A1 3353/4885TSHR 3421/4885THRB 2235/4885
US-20250332277-A1 PROTEIN TYROSINE KINASE 7 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES PTK2B, PTK2, ERBB2 ALDH1A1 3955/4885TSHR 1806/4885THRB 2257/4885
US-20260021194-A1 ANTIBODY DRUG CONJUGATE (ADC) TARGETING NECTIN 4 AND COMPRISING AN EXATECAN PAYLOAD NECTIN4, FCGR2A, FCGR3B ALDH1A1 3360/4885TSHR 113/4885THRB 1556/4885
US-20050054836-A1 Chimeric molecules to modulate gene expression MYCBP, IGF2BP1, IGF2BP3 ALDH1A1 3970/4885TSHR 1898/4885THRB 1004/4885
US-20250127916-A1 ANTIBODY DRUG CONJUGATE (ADC) TARGETING NECTIN 4 AND COMPRISING AN EXATECAN PAYLOAD NECTIN4, SDC4, EPCAM ALDH1A1 1777/4885TSHR 1104/4885THRB 2649/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.