Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 15/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.48 |
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5424050 | 0.79 | TRPM5 (0.50) | PAK4ROCK2ROCK1TRPM5IDH1 | |
| SCHEMBL13122304 | 0.78 | ROCK2 (0.61) | ROCK2ROCK1TRPM5IDH1 | |
| SCHEMBL5442447 | 0.76 | ROCK2 (0.51) | PAK4ROCK2ROCK1TRPM5IDH1 | |
| SCHEMBL10263074 | 0.76 | ROCK2 (0.61) | PAK4ROCK2ROCK1 | |
| SCHEMBL14514403 | 0.76 | ROCK2 (0.61) | PAK4ROCK2ROCK1 | |
| SCHEMBL5443094 | 0.76 | MEN1 (0.60) | ROCK2ROCK1TRPM5 | |
| SCHEMBL13122305 | 0.75 | TRPA1 (0.54) | ROCK2ROCK1TRPM5IDH1 | |
| SCHEMBL11169278 | 0.75 | MAPT (0.58) | — | |
| SCHEMBL5897571 | 0.75 | HRH3 (0.60) | — | |
| SCHEMBL2801779 | 0.75 | ROCK2 (0.73) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | PAK4 415/4885KDR 1972/4885ROCK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.