Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.51 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.51 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.47 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6282946 | 0.82 | ALDH1A1 (0.71) | ALDH1A1LOXL3LOXL2IMPDH2PDE7A | |
| SCHEMBL1992198 | 0.81 | ALDH1A1 (0.50) | ALDH1A1LOXL3LOXL2PDE7APDE7B | |
| SCHEMBL2233781 | 0.81 | LOXL3 (0.48) | ALDH1A1LOXL3LOXL2PDE7APDE7B | |
| SCHEMBL5431810 | 0.78 | KIF11 (0.47) | ALDH1A1LOXL3LOXL2PDE7APDE7B | |
| SCHEMBL9955792 | 0.77 | ALDH1A1 (0.73) | ALDH1A1LOXL3LOXL2IMPDH2PDE7A | |
| SCHEMBL11867641 | 0.73 | PARP1 (0.47) | ALDH1A1LOXL3LOXL2PDE7APDE7B | |
| SCHEMBL4454871 | 0.69 | GAA (0.56) | ALDH1A1LOXL3LOXL2IMPDH2HTT | |
| SCHEMBL4458262 | 0.68 | ALDH1A1 (0.46) | ALDH1A1LOXL3LOXL2IMPDH2CYP3A4 | |
| SCHEMBL31519931 | 0.68 | GAA (0.59) | ALDH1A1PDE7APDE7BPKMMAPK10 | |
| SCHEMBL6976082 | 0.68 | GAA (0.59) | ALDH1A1PDE7APDE7BPKMMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135454-A1 | Bicyclic pyrimidin-4(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1-receptor(vr1) | BAYLISS TRACY | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135454-A1 | Bicyclic pyrimidin-4(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1-receptor(vr1) | TRPV1, TRPV2, TRPV4 | ALDH1A1 825/4885LOXL3 3121/4885LOXL2 2908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.