SCHEMBL543646

SCHEMBL543646

COC(=O)c1cccc2nnsc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.49
LMNA P02545 3/20 0.47
KDM4E B2RXH2 3/20 0.43
ATM Q13315 2/20 0.43
KMT2A Q03164 2/20 0.43
GAA P10253 1/20 0.43
ILK Q13418 1/20 0.43
TSHR P16473 2/20 0.43
ALDH1A1 P00352 3/20 0.42
CFTR P13569 1/20 0.42
HSD17B10 Q99714 1/20 0.42
POLB P06746 2/20 0.41
TP53 P04637 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
MEN1 O00255 1/20 0.40
NSD2 O96028 1/20 0.39
BLM P54132 1/20 0.39
PSMD14 O00487 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
1,2,3-Benzothia-Diazole-7-Carboxylic Acid SCHEMBL8588144 0.94 MAPT (0.45) MAPTLMNAKDM4EATMKMT2A
SCHEMBL8530686 0.88 ALDH1A1 (0.50) MAPTLMNAKDM4EATMKMT2A
SCHEMBL6964915 0.84 MAPT (0.35) MAPTLMNAKMT2AILKALDH1A1
SCHEMBL9087618 0.83 MAPT (0.35) MAPTLMNAKDM4EKMT2AGAA
SCHEMBL9089945 0.83 NPC1 (0.44) MAPTLMNAKDM4EKMT2AALDH1A1
SCHEMBL9087862 0.83 TSHR (0.53) MAPTKDM4EKMT2AGAAILK
SCHEMBL7183586 0.83 MAPT (0.37) MAPTLMNAGAAILKALDH1A1
SCHEMBL674067 0.82 RAB9A (0.36) MAPTLMNAKDM4EATMKMT2A
SCHEMBL8051642 0.81 MAPT (0.45) MAPTLMNAKMT2AALDH1A1POLB
SCHEMBL4203207 0.81 ALDH1A1 (0.55) MAPTLMNAKDM4ETSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5851766-A Process for isolating chemically regulatable DNA sequences NOVARTIS FINANCE CORPORATION (US) 1998-12-22 US claimed
US-5804693-A TRANSGENIC PLANT, PLANT CELL OR PLANT TISSUE COMPRISING AN ENCODED ENZYME CAPABLE METABOLIZING SALICYLIC ACID NOVARTIS FINANCE CORPORATION (US) 1998-09-08 US claimed
US-5789214-A TRANSPORTATION OF PLANT TISSUES, NUCLEIC ACID PROMOTER FRAGMENTS, CODES AND EXPOSING TISSUES NOVARTIS FINANCE CORPORATION (US) 1998-08-04 US claimed
US-5777200-A Chemically regulatable and anti-pathogenic DNA sequences and uses thereof NOVARTIS FINANCE CORPORATION (US) 1998-07-07 US claimed
US-5654414-A GENETIC ENGINEERING NOVARTIS FINANCE CORPORATION (US) 1997-08-05 US claimed
US-5614395-A SCREENING FOR AGROCHEMICALS HAVING THE ABILITY TO INDUCE SYSTEMIC ACQUIRED RESISTANCE IN PLANTS CIBA-GEIGY CORPORATION (US) 1997-03-25 US claimed
EP-0733117-A1 CHEMICALLY REGULATABLE AND ANTI-PATHOGENIC DNA SEQUENCES AND USES THEREOF CIBA-GEIGY AG (CH) 1996-09-25 EP claimed
WO-1995019443-A2 CHEMICALLY REGULATABLE AND ANTI-PATHOGENIC DNA SEQUENCES AND USES THEREOF CIBA-GEIGY AG (CH) 1995-07-20 WO claimed
US-5190928-A Benzo-1,2,3-thiadiazoles CIBA-GEIGY CORPORATION (US) 1993-03-02 US claimed
EP-0313512-B1 BENZOTHIADIAZOLES AND THEIR USE IN PROCESSES AND COMPOSITIONS AGAINST PLANT DISEASES CIBA-GEIGY AG (CH) 1992-11-25 EP claimed
EP-0332104-A2 Chemically regulatable DNA sequences and genes and uses thereof CIBA-GEIGY AG (CH) 1989-09-13 EP claimed
EP-0313512-A2 Benzothiadiazoles and their use in processes and compositions against plant diseases CIBA-GEIGY AG (CH) 1989-04-26 EP claimed
EP-2141150-B1 BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF TAKEDA PHARMACEUTICAL (JP) 2013-12-11 EP disclosed
US-8481810-B2 Transgenic plants expressing a cellulase SYNGENTA PARTICIPATIONS AG (CH) 2013-07-09 US disclosed
EP-0780372-B3 3-Amino-2-mercaptobenzoic acid derivatives and processes for their preparation SYNGENTA PARTICIPATIONS AG (CH) 2013-05-22 EP disclosed
EP-0780372-B3 3-Amino-2-mercaptobenzoic acid derivatives and processes for their preparation SYNGENTA PARTICIPATIONS AG (CH) 2013-05-22 EP disclosed
EP-0384889-A2 Agent to protect plants against diseases CIBA-GEIGY AG (CH) 1990-08-29 EP disclosed
US-4931581-A CHEMICAL INTERMEDIATES FOR 1,2,3-BENZOTHIADIAZOLE DERIVATIVES CIBA-GEIGY CORPORATION (US) 1990-06-05 US disclosed
EP-0332104-A2 Chemically regulatable DNA sequences and genes and uses thereof CIBA-GEIGY AG (CH) 1989-09-13 EP disclosed
EP-0313512-A2 Benzothiadiazoles and their use in processes and compositions against plant diseases CIBA-GEIGY AG (CH) 1989-04-26 EP disclosed