Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.41 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.52 |
| ▸ | CETP | P11597 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28669438 | 1.00 | TSHR (0.61) | TSHRFUCA1CETPIDO1SRC | |
| Zinc Ion SCHEMBL28032526 | 0.96 | TSHR (0.61) | TSHRFUCA1CETPIDO1SRC | |
| Silver SCHEMBL216224 | 0.96 | TSHR (0.61) | TSHRFUCA1CETPIDO1SRC | |
| SCHEMBL10689581 | 0.96 | TSHR (0.61) | TSHRFUCA1CETPIDO1SRC | |
| SCHEMBL11756561 | 0.96 | TSHR (0.61) | TSHRFUCA1CETPIDO1SRC | |
| Potassium Ion SCHEMBL4956047 | 0.96 | TSHR (0.61) | TSHRFUCA1CETPIDO1SRC | |
| Lithium Ion SCHEMBL9446519 | 0.96 | TSHR (0.61) | TSHRFUCA1CETPIDO1SRC | |
| SCHEMBL7861818 | 0.96 | TSHR (0.61) | TSHRFUCA1CETPIDO1SRC | |
| Tetramethylammonium Ion SCHEMBL9937868 | 0.90 | TSHR (0.55) | TSHRFUCA1CETPIDO1SRC | |
| SCHEMBL11741735 | 0.89 | TSHR (0.63) | TSHRFUCA1CETPIDO1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403624-B | Diaryl thiohydantoin compound and preparation method and application thereof | 上海应用技术大学 | 2024-08-27 | — | — | CN | claimed |
| US-11814405-B2 | Pyridine sulfonamide phosphate compound, preparation method therefor, and use thereof | Shanghai Xunhe Pharmaceutical Technology Co. Ltd. (CN) | 2023-11-14 | — | — | US | claimed |
| CN-115403624-A | Diaryl thiohydantoin compound and preparation method and application thereof | 上海应用技术大学 | 2022-11-29 | — | — | CN | claimed |
| EP-1669365-A1 | Method for preparing enzymatic substrate analogs as inhibitors of bacterial heptosyl-transferases | Mutabilis SA (FR) | 2006-06-14 | — | — | EP | claimed |
| WO-2006058796-A2 | METHODS FOR PREPARING ENZYMATIC SUBSTRATE ANALOGS USEFUL AS INHIBITORS OF BACTERIAL HEPTOSYL-TRANSFERASES AND BIOLOGICAL APPLICATIONS OF THE INHIBITORS | MUTABILIS SA (FR) | 2006-06-08 | — | — | WO | claimed |
| EP-0900227-B1 | IMPROVED PROCESS FOR THE SYNTHESIS OF DIESTERS OF PHOSPHORIC ACID 2,5-DIOXO-4,4-DIPHENYL-IMIDAZOLIDIN-1-YLMETHYL ESTER | WARNER LAMBERT CO (US) | 2001-12-12 | — | — | EP | claimed |
| US-6022975-A | Process for the synthesis of diesters of phosphoric acid 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethyl ester | WARNER-LAMBERT COMPANY (US) | 2000-02-08 | — | — | US | claimed |
| EP-0900227-A1 | IMPROVED PROCESS FOR THE SYNTHESIS OF DIESTERS OF PHOSPHORIC ACID 2,5-DIOXO-4,4-DIPHENYL-IMIDAZOLIDIN-1-YLMETHYL ESTER | WARNER-LAMBERT COMPANY (US) | 1999-03-10 | — | — | EP | claimed |
| WO-1997041132-A1 | IMPROVED PROCESS FOR THE SYNTHESIS OF DIESTERS OF PHOSPHORIC ACID 2,5-DIOXO-4,4-DIPHENYL-IMIDAZOLIDIN-1-YLMETHYL ESTER | WARNER-LAMBERT COMPANY (US) | 1997-11-06 | — | — | WO | claimed |
| CN-119528984-A | Preparation method of fosphenytoin sodium | 广安凯特制药有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-114380859-B | Preparation method of dibenzyl phosphate and tetrabenzyl pyrophosphate | 威智医药股份有限公司 | 2024-11-01 | — | — | CN | disclosed |
| CN-115403624-B | Diaryl thiohydantoin compound and preparation method and application thereof | 上海应用技术大学 | 2024-08-27 | — | — | CN | disclosed |
| US-11814405-B2 | Pyridine sulfonamide phosphate compound, preparation method therefor, and use thereof | Shanghai Xunhe Pharmaceutical Technology Co. Ltd. (CN) | 2023-11-14 | — | — | US | disclosed |
| CN-114685561-B | Preparation method of fosphenytoin sodium intermediate | 四川科瑞德制药股份有限公司 | 2023-10-31 | — | — | CN | disclosed |
| US-6255492-B1 | CHEMICAL INTERMEDIATES IN PRODUCTION OF 5,5-DIPHENYL-((3-PHOSPHONOOXY)METHYL)-2,4-IMIDAZOLIDINEDIONE DISODIUM SALT; USEFUL AS ANTICONVULSANT, ANTIEPILEPTIC, AND ANTIARRHYTHMIC AGENTS | WARNER-LAMBERT COMPANY | 2001-07-03 | — | — | US | disclosed |
| CN-1051315-C | Phosphonooxymethyl ethers of taxane derivatives | BRISTOL MYERS SQUIBB CO (US) | 2000-04-12 | — | — | CN | disclosed |
| US-6022975-A | Process for the synthesis of diesters of phosphoric acid 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethyl ester | WARNER-LAMBERT COMPANY (US) | 2000-02-08 | — | — | US | disclosed |
| EP-0900227-A1 | IMPROVED PROCESS FOR THE SYNTHESIS OF DIESTERS OF PHOSPHORIC ACID 2,5-DIOXO-4,4-DIPHENYL-IMIDAZOLIDIN-1-YLMETHYL ESTER | WARNER-LAMBERT COMPANY (US) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997041132-A1 | IMPROVED PROCESS FOR THE SYNTHESIS OF DIESTERS OF PHOSPHORIC ACID 2,5-DIOXO-4,4-DIPHENYL-IMIDAZOLIDIN-1-YLMETHYL ESTER | WARNER-LAMBERT COMPANY (US) | 1997-11-06 | — | — | WO | disclosed |
| CN-1111637-A | Phosphonooxymethyl ethers of taxane derivatives | BRISTOL MYERS SQUIBB CO (US) | 1995-11-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11814405-B2 | Pyridine sulfonamide phosphate compound, preparation method therefor, and use thereof | HASPIN, PPA1, PSTPIP2 | CA1 2810/4885CA2 1136/4885TSHR 4353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.