Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 6/20 | 0.40 |
| ▸ | DRD1 | P21728 | 5/20 | 0.40 |
| ▸ | DRD5 | P21918 | 5/20 | 0.40 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6294884 | 0.89 | ADRA2A (0.46) | ADRA2ACYP2D6ADRA2BADRA2CADRA1D | |
| SCHEMBL29310310 | 0.89 | KDM4E (0.42) | ADRA2ACYP2D6ADRA2BADRA2CADRA1D | |
| SCHEMBL24688300 | 0.79 | ADRA2C (0.38) | ADRA2ACYP2D6ADRA2BADRA2CADRA1D | |
| SCHEMBL5437532 | 0.78 | DRD2 (0.39) | ADRA2ACYP2D6ADRA2BADRA2CADRA1D | |
| SCHEMBL21237602 | 0.74 | NOTUM (0.46) | ADRA2ACYP2D6ADRA2BADRA2CADRA1D | |
| SCHEMBL29310333 | 0.73 | MAOA (0.41) | CYP2D6ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL20214765 | 0.71 | MAOA (0.40) | CYP2D6MAPTDRD2DRD1DRD5 | |
| SCHEMBL5441574 | 0.71 | HTR2A (0.52) | ADRA2ACYP2D6ADRA2BADRA2CADRA1D | |
| SCHEMBL1906400 | 0.71 | DRD2 (0.53) | ADRA2ACYP2D6ADRA2BADRA2CADRA1D | |
| SCHEMBL10082732 | 0.70 | CYP2D6 (0.44) | ADRA2ACYP2D6ADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043026-A1 | Dopamine receptor modulators as antipsychotic agents | GLAXO GROUP LIMITED (GB) | 2007-02-22 | — | — | US | disclosed |
| US-20070043026-A1 | Dopamine receptor modulators as antipsychotic agents | GLAXO GROUP LIMITED (GB) | 2007-02-22 | — | — | US | disclosed |
| US-20070043026-A1 | Dopamine receptor modulators as antipsychotic agents | GLAXO GROUP LIMITED (GB) | 2007-02-22 | — | — | US | disclosed |
| US-20050222124-A1 | Benzenesulfonamide derivatives as antipsychotic agents | GLAXO GROUP LIMITED (GB) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043026-A1 | Dopamine receptor modulators as antipsychotic agents | SIGMAR1, CHRM1, OPRM1 | ADRA2A 176/4885CYP2D6 598/4885ADRA2B 168/4885 |
| US-20050222124-A1 | Benzenesulfonamide derivatives as antipsychotic agents | SIGMAR1, CNR1, CBR1 | ADRA2A 564/4885CYP2D6 184/4885ADRA2B 452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.