Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.40 |
| ▸ | HCAR1 | Q9BXC0 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22091557 | 0.78 | HCAR1 (0.34) | ALDH1A1MEN1KMT2ACNOT7HCAR1 | |
| SCHEMBL8338180 | 0.72 | ALDH1A1 (0.35) | ALDH1A1ADORA3ADORA2BLMNAALB | |
| SCHEMBL8354948 | 0.72 | ADORA2A (0.33) | ALDH1A1KDM4EADORA2BADORA2A | |
| SCHEMBL10518132 | 0.72 | ALDH1A1 (0.38) | ALDH1A1KDM4EADORA2BADORA2A | |
| SCHEMBL1992699 | 0.72 | ALDH1A1 (0.43) | ALDH1A1RAB9ATSHRADORA3ADORA2B | |
| SCHEMBL5438533 | 0.70 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2AADORA3ADORA2B | |
| SCHEMBL30670576 | 0.70 | ADRB1 (0.55) | ADORA3ADORA2ALMNA | |
| SCHEMBL12411008 | 0.68 | MEN1 (0.45) | ALDH1A1MEN1KMT2ATSHRADORA2B | |
| SCHEMBL1993927 | 0.68 | ADORA2A (0.41) | ALDH1A1NPC1RAB9ATSHRADORA3 | |
| SCHEMBL14743922 | 0.65 | ADORA3 (0.48) | ALDH1A1MEN1KMT2AHCAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135454-A1 | Bicyclic pyrimidin-4(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1-receptor(vr1) | BAYLISS TRACY | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135454-A1 | Bicyclic pyrimidin-4(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1-receptor(vr1) | TRPV1, TRPV2, TRPV4 | ALDH1A1 825/4885MEN1 4674/4885KMT2A 4422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.