Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27401142 | 0.81 | TSHR (0.36) | TSHRALDH1A1HPGDPOLBALOX15 | |
| SCHEMBL3151639 | 0.77 | SRC (0.41) | TSHRAKR1C3AKR1C2ALDH1A1HPGD | |
| SCHEMBL3172935 | 0.76 | AKR1C3 (0.36) | AKR1C3AKR1C2ALDH1A1HPGDKDM4E | |
| SCHEMBL31318197 | 0.74 | ALOX15 (0.37) | AKR1C3AKR1C2ALDH1A1HPGDKDM4E | |
| SCHEMBL6306274 | 0.72 | TPMT (0.39) | TSHRAKR1C2ALDH1A1HPGDKDM4E | |
| SCHEMBL7146446 | 0.72 | PTGS2 (0.41) | AKR1C3AKR1C2ALDH1A1HPGDKDM4E | |
| SCHEMBL7152622 | 0.72 | PTGS2 (0.41) | AKR1C3AKR1C2ALDH1A1HPGDKDM4E | |
| SCHEMBL6399236 | 0.72 | PTGS2 (0.41) | AKR1C3AKR1C2ALDH1A1HPGDKDM4E | |
| SCHEMBL3179347 | 0.72 | AKR1C3 (0.36) | TSHRAKR1C3AKR1C2ALDH1A1HPGD | |
| SCHEMBL509061 | 0.71 | AKR1B1 (0.44) | TSHRALDH1A1HPGDKDM4EPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070129252-A1 | 2-Halo-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2007-06-07 | — | — | US | disclosed |
| EP-1697321-A1 | 2-HALOGEN-6-ALKYL-PHENYL SUBSTITUTED SPIROCYCLIC TETRAMIC ACID DERIVATIVES | Bayer CropScience AG (DE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005044796-A1 | 2-HALOGEN-6-ALKYL-PHENYL SUBSTITUTED SPIROCYCLIC TETRAMIC ACID DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2005-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129252-A1 | 2-Halo-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives | TBCA, CA6, TRIP13 | TSHR 198/4885AKR1C3 914/4885AKR1C2 648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.