Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463910 | 0.86 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2TSHRHPGDMEN1 | |
| SCHEMBL10716511 | 0.82 | BLM (0.41) | ALDH1A1SMN1; SMN2TSHRHPGDMEN1 | |
| SCHEMBL8891230 | 0.80 | SMN1; SMN2 (0.43) | ALDH1A1SMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL31585050 | 0.78 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL29024036 | 0.77 | SMN1; SMN2 (0.37) | ALDH1A1SMN1; SMN2TSHRHPGDMEN1 | |
| SCHEMBL8892352 | 0.77 | BLM (0.45) | ALDH1A1SMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL5438992 | 0.76 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL8044989 | 0.73 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL8035702 | 0.72 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL9743183 | 0.71 | SMN1; SMN2 (0.43) | ALDH1A1SMN1; SMN2HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027205-A1 | Diarylmethyl derivatives as potassium channel modulators | NEUROSEARCH A/S (DK) | 2007-02-01 | — | — | US | claimed |
| EP-1644332-A1 | DIARYLMETHYL DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | Poseidon Pharmaceuticals A/S (DK) | 2006-04-12 | — | — | EP | claimed |
| WO-2005003094-A1 | DIARYLMETHYL DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | POSEIDON PHARMACEUTICALS A/S (DK) | 2005-01-13 | — | — | WO | claimed |
| US-20070027205-A1 | Diarylmethyl derivatives as potassium channel modulators | NEUROSEARCH A/S (DK) | 2007-02-01 | — | — | US | disclosed |
| EP-1644332-A1 | DIARYLMETHYL DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | Poseidon Pharmaceuticals A/S (DK) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005003094-A1 | DIARYLMETHYL DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | POSEIDON PHARMACEUTICALS A/S (DK) | 2005-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027205-A1 | Diarylmethyl derivatives as potassium channel modulators | KCNC1, KCNN3, KCNA1 | ALDH1A1 3461/4885SMN1; SMN2 3863/4885TSHR 4440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.