Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 11/20 | 0.40 |
| ▸ | CLK1 | P49759 | 10/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 9/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 9/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 8/20 | 0.34 |
| ▸ | CLK3 | P49761 | 7/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzo[D]Thiazole SCHEMBL28250460 | 0.79 | ALDH1A1 (0.66) | ALDH1A1HSD17B10DYRK1ADYRK1BCLK1 | |
| Benzo[D]Thiazole SCHEMBL11715291 | 0.76 | ALDH1A1 (0.86) | ALDH1A1HSD17B10DYRK1ADYRK1BCLK1 | |
| Benzo[D]Thiazole SCHEMBL10847268 | 0.74 | — | — | |
| Benzo[D]Thiazole SCHEMBL31388426 | 0.74 | — | — | |
| Benzo[D]Thiazole SCHEMBL451685 | 0.74 | — | — | |
| Benzo[D]Thiazole SCHEMBL8430 | 0.74 | — | — | |
| Benzo[D]Thiazole SCHEMBL900814 | 0.74 | ALDH1A1 (1.00) | ALDH1A1HSD17B10DYRK1ADYRK1BDYRK2 | |
| Benzo[D]Thiazole SCHEMBL8158562 | 0.74 | ALDH1A1 (0.58) | ALDH1A1HSD17B10DYRK1ADYRK1BCLK1 | |
| Benzo[D]Thiazole SCHEMBL27650188 | 0.72 | ALDH1A1 (0.86) | ALDH1A1HSD17B10DYRK1ADYRK1BDYRK2 | |
| Benzo[D]Thiazole SCHEMBL28176141 | 0.72 | ALDH1A1 (0.86) | ALDH1A1HSD17B10DYRK1ADYRK1BDYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110686-B2 | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators | CHUGAI SEIYAKI KABUSHIKI KAISHA (JP) | 2012-02-07 | — | — | US | disclosed |
| US-20110028514-A1 | Azoles as Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-02-03 | — | — | US | disclosed |
| US-7709510-B2 | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-05-04 | — | — | US | disclosed |
| CN-100383132-C | Pyrrole malonyl-coa decarboxylase inhibitors useful as metabolic modulators | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2008-04-23 | — | — | CN | disclosed |
| US-20040092503-A1 | Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2004-05-13 | — | — | US | disclosed |
| CN-1492762-A | Azoles as malonyl-COA decarboxylase inhibitors useful as metabolic modulators | ������ҩ��ʽ���� | 2004-04-28 | — | — | CN | disclosed |
| EP-1370260-A2 | AZOLES AS MALONYL-COA DECARBOXYLASE INHIBITORS USEFUL AS METABOLIC MODULATORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-12-17 | — | — | EP | disclosed |
| WO-2003090746-A1 | 1,3-THIAZOLES AS LXR MODULATORS IN THE TREATMENT OF CARDIOVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-11-06 | — | — | WO | disclosed |
| WO-2002066035-A2 | AZOLES AS MALONYL-COA DECARBOXYLASE INHIBITORS USEFUL AS METABOLIC MODULATORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028514-A1 | Azoles as Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators | ME3, ME1, MLYCD | ALDH1A1 215/4885HSD17B10 57/4885DYRK1A 1669/4885 |
| US-20040092503-A1 | Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators | ME1, ME3, ME2 | ALDH1A1 146/4885HSD17B10 58/4885DYRK1A 1717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.