Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.59 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.59 |
| ▸ | TDO2 | P48775 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6003495 | 0.80 | MKNK1 (0.47) | MKNK1MKNK2TDO2KDM4EGAA | |
| SCHEMBL30216493 | 0.79 | MKNK1 (0.66) | MKNK1MKNK2KDM4ELMNANPSR1 | |
| SCHEMBL2357769 | 0.78 | L3MBTL1 (0.53) | TDO2KDM4EGAAL3MBTL1LMNA | |
| SCHEMBL170710 | 0.76 | TDO2 (0.61) | TDO2KDM4EGAAL3MBTL1LMNA | |
| SCHEMBL30216497 | 0.75 | MKNK1 (1.00) | MKNK1MKNK2KMT2AMEN1 | |
| SCHEMBL3038829 | 0.74 | KDM4E (0.50) | TDO2KDM4EGAAL3MBTL1LMNA | |
| SCHEMBL12788076 | 0.74 | LMNA (0.50) | TDO2KDM4EGAAL3MBTL1LMNA | |
| SCHEMBL9168467 | 0.74 | LMNA (0.50) | TDO2KDM4EGAAL3MBTL1LMNA | |
| SCHEMBL19026193 | 0.74 | NPSR1 (0.50) | TDO2KDM4EGAAL3MBTL1LMNA | |
| SCHEMBL367037 | 0.74 | TDO2 (0.59) | TDO2KDM4EGAAL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105585583-A | Non-peptide IAP (inhibitor of apoptosis protein) antagonist as well as synthetic method and application thereof | UNIV GUANGDONG TECHNOLOGY | 2016-05-18 | — | — | CN | claimed |
| CN-105566447-A | Peptoid antagonist of anti-apoptosis protein and synthesis method and application of peptoid antagonist | UNIV GUANGDONG TECHNOLOGY | 2016-05-11 | — | — | CN | claimed |
| US-20250295652-A1 | Inhibitors of Molluscum Contagiosum Infection and Methods Using the Same | UNIV PENNSYLVANIA (US) | 2025-09-25 | — | — | US | disclosed |
| WO-2025061058-A1 | NOVEL COMPOUNDS AS IAP ANTAGONISTS | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2025-03-27 | — | — | WO | disclosed |
| CN-119638702-A | Novel compounds as IAP antagonists | 苏州亚盛药业有限公司 | 2025-03-18 | — | — | CN | disclosed |
| EP-4408833-A1 | INHIBITORS OF MOLLUSCUM CONTAGIOSUM INFECTION AND METHODS USING THE SAME | The Trustees of The University of Pennsylvania (US) | 2024-08-07 | — | — | EP | disclosed |
| US-11963994-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2024-04-23 | — | — | US | disclosed |
| WO-2023049919-A1 | INHIBITORS OF MOLLUSCUM CONTAGIOSUM INFECTION AND METHODS USING THE SAME | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2023-03-30 | — | — | WO | disclosed |
| US-20220211797-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2022-07-07 | — | — | US | disclosed |
| US-20220211797-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2022-07-07 | — | — | US | disclosed |
| CN-107915728-B | IAP inhibitors | 库里斯公司 | 2021-04-30 | — | — | CN | disclosed |
| US-20070299052-A1 | Inhibitors of IAP | GENENTECH, INC. (US) | 2007-12-27 | — | — | US | disclosed |
| US-7244851-B2 | 1-[2-Cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-pyrrolidine-2-carboxylic acid (2-phenyl-2H-pyrazol-3-yl)-amide; inhibitors of IAP, for treating malignancies | GENENTECH, INC. (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244851-B2 | 1-[2-Cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-pyrrolidine-2-carboxylic acid (2-phenyl-2H-pyrazol-3-yl)-amide; inhibitors of IAP, for treating malignancies | GENENTECH, INC. (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244851-B2 | 1-[2-Cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-pyrrolidine-2-carboxylic acid (2-phenyl-2H-pyrazol-3-yl)-amide; inhibitors of IAP, for treating malignancies | GENENTECH, INC. (US) | 2007-07-17 | — | — | US | disclosed |
| EP-1778718-A1 | INHIBITORS OF IAP | Genentech, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006014361-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2006-02-09 | — | — | WO | disclosed |
| US-20060014700-A1 | 1-[2-Cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-pyrrolidine-2-carboxylic acid (2-phenyl-2H-pyrazol-3-yl)-amide; inhibitors of IAP, for treating malignancies | GENENTECH, INC. (US) | 2006-01-19 | — | — | US | disclosed |
| EP-0031548-B1 | PROCESS FOR PREPARING 5-AMINO-1,2,3-THIADIAZOLES | UBE INDUSTRIES, LTD. (JP) | 1983-03-23 | — | — | EP | disclosed |
| EP-0031548-A1 | Process for preparing 5-amino-1,2,3-thiadiazoles | UBE INDUSTRIES, LTD. (JP) | 1981-07-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250295652-A1 | Inhibitors of Molluscum Contagiosum Infection and Methods Using the Same | ITCH, EIF2AK2, TBK1 | MKNK1 602/4885MKNK2 677/4885TDO2 3629/4885 |
| US-20070299052-A1 | Inhibitors of IAP | XIAP, BIRC5, BIRC3 | MKNK1 1831/4885MKNK2 2016/4885TDO2 4611/4885 |
| US-20220211797-A1 | INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | MKNK1 1378/4885MKNK2 1638/4885TDO2 4694/4885 |
| US-20060014700-A1 | 1-[2-Cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-pyrrolidine-2-carboxylic acid (2-phenyl-2H-pyrazol-3-yl)-amide; inhibitors of IAP, for treating malignancies | BIRC5, BIRC2, XIAP | MKNK1 1345/4885MKNK2 1144/4885TDO2 3929/4885 |
| US-11963994-B2 | Inhibitors of IAP | BIRC5, XIAP, BIRC3 | MKNK1 1378/4885MKNK2 1638/4885TDO2 4694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.