SCHEMBL170710

SCHEMBL170710

c1ccc(-c2nnsc2-c2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDO2 P48775 1/20 0.61
ALDH1A1 P00352 5/20 0.56
KDM4E B2RXH2 2/20 0.56
PPARG P37231 1/20 0.56
NCOA2 Q15596 1/20 0.56
NCOA1 Q15788 1/20 0.56
NCOA3 Q9Y6Q9 1/20 0.56
L3MBTL1 Q9Y468 5/20 0.50
LMNA P02545 5/20 0.50
TDP1 Q9NUW8 2/20 0.49
PTGS2 P35354 1/20 0.47
NPSR1 Q6W5P4 3/20 0.47
GAA P10253 1/20 0.47
MAPT P10636 4/20 0.44
CYP1A2 P05177 2/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C19 P33261 1/20 0.44
CYP2C9 P11712 1/20 0.44
HSD17B10 Q99714 1/20 0.44
KMT2A Q03164 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL367037 0.98 TDO2 (0.59) TDO2ALDH1A1KDM4EPPARGNCOA2
SCHEMBL11772421 0.89 MEN1 (0.50) TDO2ALDH1A1KDM4EPPARGNCOA2
SCHEMBL11769189 0.82 HSD17B1 (0.47) TDO2ALDH1A1KDM4EPPARGNCOA2
SCHEMBL8918835 0.82 PTGS2 (0.76) ALDH1A1LMNAPTGS2NPSR1MAPT
SCHEMBL8918833 0.82 PTGS2 (0.76) ALDH1A1LMNAPTGS2NPSR1MAPT
SCHEMBL11769207 0.79 L3MBTL1 (0.49) TDO2ALDH1A1KDM4EPPARGNCOA2
SCHEMBL2064328 0.79 ALDH1A1 (0.49) TDO2ALDH1A1KDM4EPPARGNCOA2
SCHEMBL29873679 0.79 L3MBTL1 (0.49) TDO2ALDH1A1KDM4EPPARGNCOA2
SCHEMBL2064327 0.79 ALDH1A1 (0.56) TDO2ALDH1A1KDM4EPPARGNCOA2
SCHEMBL10166468 0.76 TDO2 (0.59) TDO2ALDH1A1KDM4EPPARGNCOA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 267 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060222997-A1 Adhesion improver for photosensitive resin composition and photosensitive resin composition containing same KOBAYASHI SATOSHI 2006-10-05 US claimed
US-6835468-B2 Fluorene based polymers and light emitting diodes fabricated with the same as light emitting material KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KIST) (KR) 2004-12-28 US claimed
US-20020051895-A1 Fluorene based polymers and light emitting diodes fabricated with the same as light emitting material KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KIST) 2002-05-02 US claimed
EP-1146905-A1 COX-2 INHIBITORS IN COMBINATION WITH NMDA-BLOCKERS FOR TREATING PAIN Algos Pharmaceutical Corporation (US) 2001-10-24 EP claimed
WO-2000029022-A1 COX-2 INHIBITORS IN COMBINATION WITH CENTRALLY ACTING ANALGESICS ALGOS PHARMACEUTICAL CORPORATION (US) 2000-05-25 WO claimed
WO-2000029023-A1 COX-2 INHIBITORS IN COMBINATION WITH NMDA-BLOCKERS FOR TREATING PAIN ALGOS PHARMACEUTICAL CORPORATION (US) 2000-05-25 WO claimed
US-5876864-A Fluorene-based alternating polymers containing acetylene group and electroluminescence element using the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY 1999-03-02 US claimed
US-5807974-A POLYARYLENEVINYLENE RESIN KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1998-09-15 US claimed
US-RE34726-E Ferroelectric liquid crystal compositions containing chiral haloalkoxy tail units DISPLAYTECH, INC. (US) 1994-09-13 US claimed
US-5167855-A Electrooptics and display devices UNIVERSITY RESEARCH CORPORATION (US) 1992-12-01 US claimed
US-5130048-A Enantiomorphs for optical apparatus DISPLAYTECH, INC. (US) 1992-07-14 US claimed
US-11905525-B2 Reduction of elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins MODERNATX, INC. (US) 2024-02-20 US disclosed
US-20230403928-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2023-12-14 US disclosed
US-11435363-B2 Relevance of achieved levels of markers of systemic inflammation following treatment THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2022-09-06 US disclosed
US-20220047518-A1 PEG LIPIDS AND USES THEREOF Moderna TX, Inc. (US) 2022-02-17 US disclosed
WO-2000029022-A1 COX-2 INHIBITORS IN COMBINATION WITH CENTRALLY ACTING ANALGESICS ALGOS PHARMACEUTICAL CORPORATION (US) 2000-05-25 WO disclosed
US-5876864-A Fluorene-based alternating polymers containing acetylene group and electroluminescence element using the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY 1999-03-02 US disclosed
US-5807974-A POLYARYLENEVINYLENE RESIN KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1998-09-15 US disclosed
US-5759444-A FLAT LIGHT SOURCE OR DISPLAY; BRIGHTNESS, STABILITY TOYO INK MANUFACTURING CO., LTD. (JP) 1998-06-02 US disclosed
US-5677318-A Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents MERCK FROSST CANADA, INC. (CA) 1997-10-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220047518-A1 PEG LIPIDS AND USES THEREOF LIPA, LIPG, LNPEP TDO2 4616/4885ALDH1A1 1384/4885KDM4E 2303/4885
US-11905525-B2 Reduction of elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins CD47, FCGR3B, MSR1 TDO2 4841/4885ALDH1A1 3761/4885KDM4E 3474/4885
US-20230403928-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME CRY1, CYP1A1, CYP2E1 TDO2 552/4885ALDH1A1 13/4885KDM4E 2491/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.