SCHEMBL544660

SCHEMBL544660

Cc1cc(C)c(O)c(Cc2ccccc2)c1

nearest known ligand 0.66

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 1/20 0.52
BCL2L1 Q07817 1/20 0.52
PTPN1 P18031 2/20 0.47
PTPN2 P17706 1/20 0.47
PTPN6 P29350 1/20 0.47
LDHA P00338 1/20 0.47
LDHB P07195 1/20 0.47
EGFR P00533 1/20 0.46
ERBB2 P04626 1/20 0.46
AMY1A P0DUB6 1/20 0.46
ALOX5 P09917 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL670158 0.90 BCL2 (0.57) BCL2BCL2L1PTPN1PTPN2PTPN6
SCHEMBL1904809 0.89 AMY1A (0.58) BCL2BCL2L1PTPN1PTPN2PTPN6
SCHEMBL545616 0.87 AMY1A (0.52) EGFRERBB2AMY1AALOX5
SCHEMBL31146662 0.85 SHBG (0.61) BCL2BCL2L1PTPN1PTPN2PTPN6
SCHEMBL8680810 0.85 EGFR (0.49) EGFRERBB2AMY1A
SCHEMBL8990148 0.85 BCL2 (0.52) BCL2BCL2L1PTPN1PTPN2PTPN6
SCHEMBL28693854 0.84 IDH1 (0.49) EGFRERBB2AMY1A
SCHEMBL31603741 0.84 PTGS1 (0.47) BCL2BCL2L1EGFRERBB2ALOX5
SCHEMBL10905506 0.83 PTPN1 (0.50) BCL2BCL2L1PTPN1PTPN2PTPN6
SCHEMBL5685298 0.82 SHBG (0.57) EGFRERBB2AMY1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115243764-B Heterocyclic derivatives as TRMP antagonists 奇华顿股份有限公司 2025-01-03 CN disclosed
CN-118813293-A High-density hydrocarbon fuel and preparation method thereof 陕西煤基特种燃料研究院有限公司 2024-10-22 CN disclosed
CN-118813292-A High-density fuel and production method thereof 陕西煤基特种燃料研究院有限公司 2024-10-22 CN disclosed
US-20230098332-A1 HETEROCYCLIC DERIVATIVES AS TRMP8 ANTAGONISTS GIVAUDAN SA (CH) 2023-03-30 US disclosed
EP-4114523-A1 HETEROCYCLIC DERIVATIVES AS TRMP8 ANTAGONISTS Givaudan SA (CH) 2023-01-11 EP disclosed
CN-115243764-A Heterocyclic derivatives as TRMP8 antagonists 奇华顿股份有限公司 2022-10-25 CN disclosed
US-8110589-B2 Ectoparasiticide composition and a method for exterminating extoparasites KYOYU AGRI CO., LTD. (JP) 2012-02-07 US disclosed
US-20090312378-A1 ECTOPARASITICIDE COMPOSITION AND A METHOD FOR EXTERMINATING ECTOPARASITES YASHIMA SANGYO CO., LTD. (JP) 2009-12-17 US disclosed
US-7202018-B2 Silver salt photothermographic dry imaging material KONICA CORPORATION (JP) 2007-04-10 US disclosed
CN-1072811-C Novel matrix resin for high-temperature stable photoimageable compositions 科莱恩金融(BVI)有限公司 2001-10-10 CN disclosed
EP-0451761-B1 Organic electronic material and electrophotographic photosensitive member containing it CANON KK (JP) 1996-07-03 EP disclosed
US-5176976-A Stilbenequinones as stable charge transfer compounds CANON KABUSHIKI KAISHA (JP) 1993-01-05 US disclosed
EP-0451761-A1 Organic electronic material and electrophotographic photosensitive member containing it CANON KABUSHIKI KAISHA (JP) 1991-10-16 EP disclosed
EP-0186255-A2 Process for preparing benzyl substituted phenols, dibenzylphenolic compounds, and the antioxidant use of such phenols ETHYL CORPORATION (US) 1986-07-02 EP disclosed
US-4514577-A ANTIOXIDANTS ETHYL CORPORATION (US) 1985-04-30 US disclosed
US-3991139-A NORBORNENE DERIVATIVES, PHENOLS, ESTER THIOETHERS SHOWA DENKO KABUSHIKI KAISHA (JA) 1976-11-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230098332-A1 HETEROCYCLIC DERIVATIVES AS TRMP8 ANTAGONISTS TRPM8, TRPM7, TRPM5 BCL2 3046/4885BCL2L1 3362/4885PTPN1 4238/4885
US-20090312378-A1 ECTOPARASITICIDE COMPOSITION AND A METHOD FOR EXTERMINATING ECTOPARASITES EPX, TYR, PPOX BCL2 1991/4885BCL2L1 3079/4885PTPN1 2086/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.