Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | AGXT | P21549 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | TPMT | P51580 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7259829 | 0.90 | RAB9A (0.50) | MAOBRAB9APTPN1NPC1MAPK8 | |
| SCHEMBL966965 | 0.83 | SIGMAR1 (0.46) | MAOBRAB9APTPN1NPC1MAPK8 | |
| SCHEMBL7263857 | 0.81 | CES2 (0.47) | MAOBMAPK8IDO1AGXTCES2 | |
| SCHEMBL7265238 | 0.80 | ALDH1A1 (0.49) | MAOBRAB9ATPMTALDH1A1LMNA | |
| SCHEMBL12218359 | 0.77 | MAPK8 (0.52) | RAB9ANPC1MAPK8MEN1ALDH1A1 | |
| SCHEMBL5643140 | 0.77 | EPHX2 (0.54) | MAOBMEN1KMT2A | |
| SCHEMBL375135 | 0.76 | KMT2A (0.41) | MAOBMAPK8GRIN2BIDO1AGXT | |
| SCHEMBL16257133 | 0.75 | IDO1 (0.46) | MAOBMAPK8IDO1AGXTCES2 | |
| SCHEMBL8724147 | 0.75 | GRIN2B (0.40) | MAOBRAB9AGRIN2BCES2CES1 | |
| SCHEMBL1288294 | 0.75 | IDO1 (0.48) | MAOBMAPK8IDO1AGXTCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027115-A1 | Triazole derivatives useful in therapy | PFIZER INC. | 2007-02-01 | — | — | US | disclosed |
| US-6977302-B2 | Triazole derivatives useful in therapy | AGOURON PHARMACEUTICALS, INC. (US) | 2005-12-20 | — | — | US | disclosed |
| US-20050130940-A1 | Triazole derivatives useful in therapy | PFIZER INC. | 2005-06-16 | — | — | US | disclosed |
| US-20040236105-A1 | Triazole derivatives useful in therapy | PFIZER, INC. | 2004-11-25 | — | — | US | disclosed |
| US-6790957-B2 | CONVERTING TERTIARY HYDROXY GROUP OF A TRIAZOLE ANTIFUNGAL COMPOUND INTO A PHOSPHATE GROUP TO IMPROVE AQUEOUS SOLUBILITY | PFIZER, INC. | 2004-09-14 | — | — | US | disclosed |
| US-20030144250-A1 | Triazole derivatives useful in therapy | GREEN STUART (GB) | 2003-07-31 | — | — | US | disclosed |
| EP-0835252-B1 | TRIAZOLE ANTIFUNGAL AGENTS | PFIZER RES & DEV (IE) | 2003-07-30 | — | — | EP | disclosed |
| EP-0880533-B1 | Triazole derivatives useful in therapy | PFIZER RES & DEV (IE) | 2002-06-12 | — | — | EP | disclosed |
| US-6376526-B1 | FOR HUANS, ANIMALS | PFIZER INC. | 2002-04-23 | — | — | US | disclosed |
| EP-0796858-B1 | Triazole antifungal agents | PFIZER LTD (GB) | 2000-11-02 | — | — | EP | disclosed |
| US-6124325-A | Triazole antifungal agents | PFIZER INC. (US) | 2000-09-26 | — | — | US | disclosed |
| US-6015825-A | Triazole antifungal agents | PFIZER INC. (US) | 2000-01-18 | — | — | US | disclosed |
| US-5981560-A | 1,2,4-TRIAZOLE FUNGICIDES | PFIZER INC. (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0880533-A1 | TRIAZOLE DERIVATIVES USEFUL IN THERAPY | Pfizer Research and Development Company, N.V./S.A. (IE) | 1998-12-02 | — | — | EP | disclosed |
| EP-0835252-A1 | TRIAZOLE ANTIFUNGAL AGENTS | Pfizer Research and Development Company, N.V./S.A. (IE) | 1998-04-15 | — | — | EP | disclosed |
| EP-0796858-A1 | Triazole antifungal agents | Pfizer Limited (GB) | 1997-09-24 | — | — | EP | disclosed |
| WO-1997028169-A1 | TRIAZOLE DERIVATIVES USEFUL IN THERAPY | PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) | 1997-08-07 | — | — | WO | disclosed |
| WO-1997001552-A1 | TRIAZOLE ANTIFUNGAL AGENTS | PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) | 1997-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130940-A1 | Triazole derivatives useful in therapy | ERG28, CYP51A1, THOP1 | MAOB 944/4885RAB9A 3498/4885PTPN1 356/4885 |
| US-20070027115-A1 | Triazole derivatives useful in therapy | ERG28, CYP51A1, THOP1 | MAOB 944/4885RAB9A 3498/4885PTPN1 356/4885 |
| US-20030144250-A1 | Triazole derivatives useful in therapy | CYP51A1, THOP1, ERG28 | MAOB 725/4885RAB9A 3400/4885PTPN1 184/4885 |
| US-20040236105-A1 | Triazole derivatives useful in therapy | CYP51A1, ERG28, THOP1 | MAOB 396/4885RAB9A 4034/4885PTPN1 482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.