Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 16/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5452648 | 1.00 | CCR5 (0.42) | CCR5KMT2APRCPALDH1A1 | |
| SCHEMBL5867337 | 0.94 | KMT2A (0.41) | CCR5KMT2APRCPALDH1A1 | |
| SCHEMBL5867355 | 0.94 | SIGMAR1 (0.43) | CCR5KMT2APRCP | |
| Hydrochloric Acid SCHEMBL5463380 | 0.93 | SIGMAR1 (0.43) | CCR5KMT2APRCP | |
| Hydrochloric Acid SCHEMBL5448681 | 0.93 | KMT2A (0.41) | CCR5KMT2APRCPALDH1A1 | |
| SCHEMBL5868117 | 0.93 | HTR7 (0.42) | CCR5KMT2APRCP | |
| Hydrochloric Acid SCHEMBL5459369 | 0.92 | HTR7 (0.41) | CCR5KMT2APRCP | |
| SCHEMBL6715399 | 0.90 | PRCP (0.40) | CCR5KMT2APRCP | |
| SCHEMBL5458123 | 0.90 | KMT2A (0.44) | CCR5KMT2A | |
| Hydrochloric Acid SCHEMBL5458549 | 0.89 | KMT2A (0.43) | CCR5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070117847-A1 | N-(3-(4-Substituted-1-piperiding1)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists | CHAMBERS MARK S | 2007-05-24 | — | — | US | disclosed |
| US-7153868-B2 | N-(3-(4-substituted-1-piperidinyl)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists | MERCK SHARP & DOHME LTD. | 2006-12-26 | — | — | US | disclosed |
| US-20040002504-A1 | N-(3-(4-substituted-1-piperidinyl)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists | MERCK SHARP & DOHME LTD. (GB) | 2004-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040002504-A1 | N-(3-(4-substituted-1-piperidinyl)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists | KCNH3, KCNH2, KCNK3 | CCR5 710/4885KMT2A 480/4885PRCP 2192/4885 |
| US-20070117847-A1 | N-(3-(4-Substituted-1-piperiding1)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists | TACR2, KCNK3, KCNH3 | CCR5 1040/4885KMT2A 763/4885PRCP 3144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.