Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | KHK | P50053 | 2/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17738349 | 0.82 | HDAC1 (0.39) | MEN1USP2GAAKMT2AADRA2C | |
| SCHEMBL28936369 | 0.82 | HDAC1 (0.42) | MEN1USP2GAAKMT2AADRA2C | |
| SCHEMBL21281577 | 0.81 | ADRB1 (0.61) | ALDH1A1LMNAHTR2CKHKADRB1 | |
| SCHEMBL21268764 | 0.81 | ADRB1 (0.61) | ALDH1A1LMNAHTR2CKHKADRB1 | |
| SCHEMBL21268746 | 0.81 | ADRB1 (0.61) | ALDH1A1LMNAHTR2CKHKADRB1 | |
| SCHEMBL546772 | 0.81 | KMT2A (0.56) | MEN1USP2GAAKMT2AADRA2C | |
| SCHEMBL2249111 | 0.80 | NOTUM (0.48) | ALDH1A1LMNAHTR2CKHKKDM4E | |
| SCHEMBL2246683 | 0.80 | NOTUM (0.48) | ALDH1A1LMNAHTR2CKHKKDM4E | |
| SCHEMBL5268435 | 0.80 | NOTUM (0.48) | ALDH1A1LMNAHTR2CKHKKDM4E | |
| SCHEMBL2456774 | 0.80 | ALDH1A1 (0.44) | ADRA2CHDAC1ALDH1A1LMNAHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436271-B3 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H LUNDBECK AS (DK) | 2022-04-20 | — | — | EP | disclosed |
| US-20210276966-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | H. LUNDBECK A/S (DK) | 2021-09-09 | — | — | US | disclosed |
| US-10844029-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2020-11-24 | — | — | US | disclosed |
| US-20180127389-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | H. LUNDBECK A/S (DK) | 2018-05-10 | — | — | US | disclosed |
| US-9708280-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2017-07-18 | — | — | US | disclosed |
| US-20160137620-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | H. LUNDBECK A/S (DK) | 2016-05-19 | — | — | US | disclosed |
| US-9090575-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2015-07-28 | — | — | US | disclosed |
| US-20140163043-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2014-06-12 | — | — | US | disclosed |
| US-8476279-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2013-07-02 | — | — | US | disclosed |
| US-20120302553-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2012-11-29 | — | — | US | disclosed |
| US-7138407-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2006-11-21 | — | — | US | disclosed |
| US-7067501-B2 | Aryloxyphenyl and arylsulfanylphenyl derivatives | H. LUNDBECK A/S (DK) | 2006-06-27 | — | — | US | disclosed |
| US-20060089368-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2006-04-27 | — | — | US | disclosed |
| US-20060084662-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2006-04-20 | — | — | US | disclosed |
| US-20050171061-A1 | Aryloxyphenyl and arylsulfanylphenyl derivatives | H. LUNDBECK A/S (DK) | 2005-08-04 | — | — | US | disclosed |
| US-20050014740-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2005-01-20 | — | — | US | disclosed |
| EP-1458689-A1 | ARYLOXYPHENYL AND ARYLSULFANYLPHENYL DERIVATIVES | H. LUNDBECK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| EP-1436271-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. Lundbeck A/S (DK) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003053942-A1 | ARYLOXYPHENYL AND ARYLSULFANYLPHENYL DERIVATIVES | H. LUNDBECK A/S (DK) | 2003-07-03 | — | — | WO | disclosed |
| WO-2003029232-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089368-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | TPH1, HTR5A, HTR2C | MEN1 4416/4885USP2 3794/4885GAA 1105/4885 |
| US-20140163043-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | TPH1, HTR5A, HTR2C | MEN1 4416/4885USP2 3794/4885GAA 1105/4885 |
| US-20050014740-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | TPH1, HTR5A, HTR2C | MEN1 4416/4885USP2 3794/4885GAA 1105/4885 |
| US-20180127389-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | TPH1, HTR5A, HTR2C | MEN1 4416/4885USP2 3794/4885GAA 1105/4885 |
| US-20060084662-A1 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | TPH1, HTR5A, HTR2C | MEN1 4416/4885USP2 3794/4885GAA 1105/4885 |
| US-20210276966-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | TPH1, HTR5A, HTR2C | MEN1 4416/4885USP2 3794/4885GAA 1105/4885 |
| US-20120302553-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | TPH1, HTR5A, HTR2C | MEN1 4416/4885USP2 3794/4885GAA 1105/4885 |
| US-20160137620-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | TPH1, HTR5A, HTR2C | MEN1 4416/4885USP2 3794/4885GAA 1105/4885 |
| US-20050171061-A1 | Aryloxyphenyl and arylsulfanylphenyl derivatives | SLC1A5, SLC6A7, SLC6A19 | MEN1 2743/4885USP2 3807/4885GAA 304/4885 |
| US-10844029-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | TPH1, HTR5A, HTR2C | MEN1 4416/4885USP2 3794/4885GAA 1105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.