Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6517662 | 0.81 | INSR (0.44) | ACHEHSD17B10KMT2ARAB9AHSP90AA1 | |
| SCHEMBL5176140 | 0.78 | SMN1; SMN2 (0.44) | KMT2ARAB9ACYP3A4ALDH1A1LMNA | |
| SCHEMBL11748071 | 0.75 | MAPT (0.53) | ACHEHSD17B10KMT2ARAB9AHSP90AA1 | |
| SCHEMBL10391152 | 0.75 | SMN1; SMN2 (0.33) | KMT2ARAB9ACYP3A4ALDH1A1LMNA | |
| SCHEMBL11666197 | 0.74 | CYP1A2 (0.41) | KMT2ARAB9AHSP90AA1GFERINSR | |
| SCHEMBL12005031 | 0.73 | LMNA (0.35) | ACHEHSD17B10KMT2ARAB9AHSP90AA1 | |
| SCHEMBL11732864 | 0.72 | HSP90AA1 (0.46) | ACHEHSD17B10KMT2ARAB9AHSP90AA1 | |
| SCHEMBL7740556 | 0.69 | ACHE (0.41) | ACHEHSD17B10KMT2ARAB9AHSP90AA1 | |
| Toliodium SCHEMBL5405412 | 0.67 | ACHE (0.58) | ACHEHSD17B10KMT2ARAB9AHSP90AA1 | |
| SCHEMBL6909417 | 0.66 | GAA (0.62) | HSD17B10KMT2ACYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166715-B2 | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds | APPLERA CORPORATION (US) | 2007-01-23 | — | — | US | disclosed |
| US-20050009058-A1 | As quencher in reporter-quencher energy-transfer dye pair for nucleic acid hybridization assays; hairpin motif | APPLERA CORPORATION (US) | 2005-01-13 | — | — | US | disclosed |
| US-6750024-B2 | USEFUL AS QUENCHERS IN A REPORTER-QUENCHER ENERGY-TRANSFER DYE PAIR | APPLERA CORPORATION | 2004-06-15 | — | — | US | disclosed |
| US-20030207305-A1 | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds | APPLERA CORPORATION (US) | 2003-11-06 | — | — | US | disclosed |
| US-6541618-B1 | Detecting hybrids | APPLERA CORPORATION | 2003-04-01 | — | — | US | disclosed |
| US-6348596-B1 | NUCLEIC ACID HYBRIDIZATION ASSAYS; DNA SEQUENCE DETERMINATION | PE CORPORATION (NY) | 2002-02-19 | — | — | US | disclosed |
| EP-1049744-B1 | ASYMMETRIC CYANINE DYE QUENCHERS | PE CORP NY (US) | 2002-01-23 | — | — | EP | disclosed |
| EP-1049744-A1 | ASYMMETRIC CYANINE DYE QUENCHERS | PE Corporation (NY) (US) | 2000-11-08 | — | — | EP | disclosed |
| US-6080868-A | AS A QUENCHER IN A REPORTER-QUENCHER ENERGY-TRANSFER DYE PAIR FOR NUCLEIC ACID HYBRIDIZATION ASSAYS | THE PERKIN-ELMER CORPORATION (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1999037717-A1 | ASYMMETRIC CYANINE DYE QUENCHERS | THE PERKIN-ELMER CORPORATION (US) | 1999-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207305-A1 | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds | NSUN3, NSUN2, NCL | ACHE 2619/4885HSD17B10 3566/4885KMT2A 2454/4885 |
| US-20050009058-A1 | As quencher in reporter-quencher energy-transfer dye pair for nucleic acid hybridization assays; hairpin motif | NSUN3, SRRT, RNGTT | ACHE 3457/4885HSD17B10 2924/4885KMT2A 3319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.