Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5471801 | 0.94 | POLB (0.48) | PTGS2RORCCA1CA2CA9 | |
| SCHEMBL5470986 | 0.89 | RORC (0.43) | RORCNPC1POLBRAB9AKDM4E | |
| SCHEMBL5470932 | 0.88 | MAPT (0.43) | PTGS2RORCCA12CA1CA2 | |
| SCHEMBL5473013 | 0.88 | LMNA (0.44) | PTGS2RORCCA12CA1CA2 | |
| SCHEMBL5477205 | 0.81 | NPC1 (0.49) | NFKB1NPC1POLBRAB9AKDM4E | |
| SCHEMBL5467459 | 0.81 | LMNA (0.47) | RORCPOLBMEN1KMT2AMAPT | |
| SCHEMBL5476172 | 0.80 | MEN1 (0.43) | RORCCA1CA2CA9POLB | |
| SCHEMBL5471818 | 0.80 | POLB (0.52) | RORCCA1CA2CA9NFKB1 | |
| SCHEMBL5479371 | 0.80 | PTGS2 (0.45) | PTGS2RORCNFKB1POLBKDM4E | |
| SCHEMBL5474346 | 0.79 | PDE4B (0.46) | CA1CA2CA9POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161637-A1 | Substituted pyridin-2-ylamine analogues | NEUROGEN CORPORATION (US) | 2007-07-12 | — | — | US | claimed |
| EP-1648877-A1 | SUBSTITUTED PYRIDIN-2-YLAMINE ANALOGUES | NEUROGEN CORPORATION (US) | 2006-04-26 | — | — | EP | claimed |
| WO-2005009980-A1 | SUBSTITUTED PYRIDIN-2-YLAMINE ANALOGUES | NEUROGEN CORPORATION (US) | 2005-02-03 | — | — | WO | claimed |
| US-20070161637-A1 | Substituted pyridin-2-ylamine analogues | NEUROGEN CORPORATION (US) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161637-A1 | Substituted pyridin-2-ylamine analogues | PIGS, GPR35, GPR174 | PTGS2 1015/4885RORC 506/4885CA12 4847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.