Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5470932 | 0.92 | MAPT (0.43) | PDE4BPDE4DMAPTLMNAMEN1 | |
| SCHEMBL5476920 | 0.92 | ALDH1A1 (0.43) | PDE4BPDE4DMAPTLMNAMEN1 | |
| SCHEMBL5471801 | 0.84 | POLB (0.48) | PDE4BPDE4DMAPTLMNAMEN1 | |
| SCHEMBL5476172 | 0.84 | MEN1 (0.43) | PDE4BPDE4DMAPTLMNAMEN1 | |
| SCHEMBL5467459 | 0.82 | LMNA (0.47) | PDE4BPDE4DMAPTLMNAMEN1 | |
| SCHEMBL5476954 | 0.81 | GAA (0.49) | MAPTMEN1KMT2AALDH1A1PTK2 | |
| SCHEMBL5470979 | 0.81 | ALDH1A1 (0.46) | PDE4BPDE4DMAPTLMNAMEN1 | |
| SCHEMBL5477116 | 0.79 | PTGS2 (0.45) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL5470964 | 0.78 | PTK2 (0.52) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5467461 | 0.77 | DHFR (0.40) | MAPTLMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161637-A1 | Substituted pyridin-2-ylamine analogues | NEUROGEN CORPORATION (US) | 2007-07-12 | — | — | US | claimed |
| EP-1648877-A1 | SUBSTITUTED PYRIDIN-2-YLAMINE ANALOGUES | NEUROGEN CORPORATION (US) | 2006-04-26 | — | — | EP | claimed |
| WO-2005009980-A1 | SUBSTITUTED PYRIDIN-2-YLAMINE ANALOGUES | NEUROGEN CORPORATION (US) | 2005-02-03 | — | — | WO | claimed |
| US-20070161637-A1 | Substituted pyridin-2-ylamine analogues | NEUROGEN CORPORATION (US) | 2007-07-12 | — | — | US | disclosed |
| US-20070161637-A1 | Substituted pyridin-2-ylamine analogues | NEUROGEN CORPORATION (US) | 2007-07-12 | — | — | US | disclosed |
| US-20070161637-A1 | Substituted pyridin-2-ylamine analogues | NEUROGEN CORPORATION (US) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161637-A1 | Substituted pyridin-2-ylamine analogues | PIGS, GPR35, GPR174 | PDE4B 995/4885PDE4D 1352/4885MAPT 3278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.