Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5333197 | 0.89 | RAB9A (0.44) | PDGFRBPDGFRAALDH1A1HPGDMAPT | |
| SCHEMBL9989497 | 0.77 | PDGFRB (0.50) | PDGFRBPDGFRAALDH1A1HPGDMAPT | |
| SCHEMBL15865580 | 0.77 | PDGFRB (0.50) | PDGFRBPDGFRAALDH1A1HPGDMAPT | |
| SCHEMBL17519203 | 0.77 | PDGFRB (0.50) | PDGFRBPDGFRAALDH1A1HPGDMAPT | |
| SCHEMBL20502182 | 0.76 | MGMT (0.38) | PDGFRBPDGFRAALDH1A1MAPTKMT2A | |
| SCHEMBL30421289 | 0.76 | MGMT (0.38) | PDGFRBPDGFRAALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL30023354 | 0.74 | MGMT (0.37) | PDGFRBPDGFRAALDH1A1MAPTKMT2A | |
| SCHEMBL4729387 | 0.73 | ALDH1A1 (0.49) | PDGFRBPDGFRAALDH1A1HPGDMAPT | |
| SCHEMBL18922689 | 0.73 | PDGFRB (0.47) | PDGFRBPDGFRAALDH1A1HPGDMAPT | |
| SCHEMBL11996183 | 0.73 | PDGFRB (0.47) | PDGFRBPDGFRAALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3247692-B1 | INHIBITORS OF TRKA KINASE | GVK BIOSCIENCES PRIVATE LTD (IN) | 2022-09-07 | — | — | EP | disclosed |
| US-10336723-B2 | Inhibitors of TrkA kinase | GVK BIOSCIENCES PRIVATE LIMITED (IN) | 2019-07-02 | — | — | US | disclosed |
| US-20180009781-A1 | INHIBITORS OF TRKA KINASE | GVK BIOSCIENCES PRIVATE LIMITED (IN) | 2018-01-11 | — | — | US | disclosed |
| EP-3247692-A1 | INHIBITORS OF TRKA KINASE | GVK Biosciences Private Limited (IN) | 2017-11-29 | — | — | EP | disclosed |
| WO-2016116900-A1 | INHIBITORS OF TRKA KINASE | GVK BIOSCIENCES PRIVATE LIMITED (IN) | 2016-07-28 | — | — | WO | disclosed |
| US-20070225318-A1 | Pyrazole Compounds Useful In The Treatment Of Inflammation | BIOLIPOX AB (SE) | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225318-A1 | Pyrazole Compounds Useful In The Treatment Of Inflammation | ALOX15, ALOX15B, ALOX12 | PDGFRB 1848/4885PDGFRA 2096/4885ALDH1A1 306/4885 |
| US-20180009781-A1 | INHIBITORS OF TRKA KINASE | NGFR, NGF, NTRK1 | PDGFRB 30/4885PDGFRA 22/4885ALDH1A1 2186/4885 |
| US-10336723-B2 | Inhibitors of TrkA kinase | NGFR, EDNRA, NGF | PDGFRB 28/4885PDGFRA 17/4885ALDH1A1 2317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.