Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.51 |
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.46 |
| ▸ | CTSA | P10619 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | RORB | Q92753 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7762502 | 0.84 | BCAT2 (0.56) | BCAT2CTSAP2RX3LMNACHEK1 | |
| SCHEMBL5724135 | 0.81 | PARP1 (0.56) | BCAT2CTSAP2RX3LMNACHEK1 | |
| SCHEMBL31583298 | 0.81 | BCAT2 (0.51) | BCAT2RORBCHEK1PDK2 | |
| SCHEMBL6187171 | 0.80 | BCAT2 (0.50) | MAPK8MAPK10BCAT2RORBLMNA | |
| SCHEMBL21357032 | 0.80 | PTGS2 (0.58) | BCAT2CTSALMNAHTT | |
| SCHEMBL27635470 | 0.80 | BCAT2 (0.63) | BCAT2S1PR1RORBLMNACHEK1 | |
| SCHEMBL27635469 | 0.77 | BCAT2 (0.62) | ARBCAT2LMNACHEK1PDK2 | |
| SCHEMBL6187361 | 0.77 | BCAT2 (0.44) | MAPK8MAPK10BCAT2CHEK1PDK2 | |
| SCHEMBL9077062 | 0.76 | RARA (0.56) | HTT | |
| SCHEMBL25295556 | 0.75 | ALDH1A1 (0.52) | MAPK8BCAT2CTSALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | claimed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | claimed |