Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593885 | 0.83 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPK1CYP1A2KDM4EALDH1A1 | |
| SCHEMBL4594912 | 0.83 | ALDH1A1 (0.38) | SMN1; SMN2MAPK1CYP1A2KDM4EALDH1A1 | |
| SCHEMBL4594020 | 0.81 | PAOX (0.38) | SMN1; SMN2MAPK1CYP1A2KDM4EALDH1A1 | |
| SCHEMBL4594022 | 0.77 | HRH2 (0.38) | SMN1; SMN2MAPK1KDM4EALDH1A1HRH2 | |
| SCHEMBL9644791 | 0.76 | HSD17B10 (0.52) | HSD17B10SMN1; SMN2MAPK1CYP1A2ALDH1A1 | |
| SCHEMBL4594578 | 0.76 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPK1CYP1A2KDM4EALDH1A1 | |
| SCHEMBL4593888 | 0.76 | HRH2 (0.37) | SMN1; SMN2MAPK1KDM4EALDH1A1HRH2 | |
| SCHEMBL18107078 | 0.75 | ACHE (0.35) | CYP1A2HRH2HRH1HRH3ACHE | |
| SCHEMBL4593996 | 0.75 | MMP2 (0.39) | SMN1; SMN2MAPK1CYP1A2KDM4EALDH1A1 | |
| SCHEMBL4594907 | 0.75 | HRH2 (0.37) | SMN1; SMN2MAPK1KDM4EALDH1A1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166605-B2 | Probucol nitro-derivatives | NICOX, S.A. (FR) | 2007-01-23 | — | — | US | claimed |
| US-20060167003-A1 | Probucol derivatives | NICOX S.A. (FR) | 2006-07-27 | — | — | US | claimed |
| US-20060167003-A1 | Probucol derivatives | NICOX S.A. (FR) | 2006-07-27 | — | — | US | disclosed |
| EP-1521740-A2 | PROBUCOL DERIVATIVES | Nicox S.A. (FR) | 2005-04-13 | — | — | EP | disclosed |
| WO-2003080568-A2 | PROBUCOL DERIVATIVES | NICOX S.A. (FR) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167003-A1 | Probucol derivatives | PNLIP, APOB, LIPC | HSD17B10 452/4885SMN1; SMN2 741/4885MAPK1 2788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.