SCHEMBL5494536

SCHEMBL5494536

Cc1ccc(C(C)C[Si](Cl)(Cl)Cl)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.44
STAT3 P40763 1/20 0.41
GRIA4 P48058 1/20 0.39
CHRNA7 P36544 1/20 0.37
TDP1 Q9NUW8 1/20 0.35
CA2 P00918 3/20 0.33
ALDH1A1 P00352 3/20 0.33
CA9 Q16790 2/20 0.33
CYP19A1 P11511 2/20 0.33
CA12 O43570 1/20 0.33
TSHR P16473 1/20 0.33
CA1 P00915 2/20 0.33
CA7 P43166 1/20 0.33
LMNA P02545 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ALOX5 P09917 1/20 0.32
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32
AOC3 Q16853 1/20 0.32
UTS2R Q9UKP6 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11213578 0.87 ACHE (0.44) ACHESTAT3GRIA4CHRNA7TDP1
SCHEMBL5490217 0.84 IDO1 (0.38) SMN1; SMN2ESR1ESR2AOC3
SCHEMBL5484319 0.83 ADRB2 (0.46) TDP1CYP19A1TSHRLMNAAOC3
SCHEMBL5489949 0.81 AOC3 (0.35) CA2ALDH1A1CA1AOC3
SCHEMBL5487989 0.81 PYCR1 (0.37) ALDH1A1SMN1; SMN2ALOX5
SCHEMBL5413664 0.80 TAAR1 (0.52) ALDH1A1TSHRAOC3
SCHEMBL18270303 0.80 ACHE (0.46) ACHESTAT3GRIA4CHRNA7TDP1
SCHEMBL5491106 0.79 L3MBTL1 (0.48) TDP1ALDH1A1TSHRLMNASMN1; SMN2
SCHEMBL11839524 0.79 ESR1 (0.38) TDP1CA2TSHRCA1ESR1
SCHEMBL9079639 0.79 ACHE (0.39) ACHESTAT3GRIA4CHRNA7CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7291747-B2 Silicon compounds and process for preparation thereof CHISSO CORPORATION (JP) 2007-11-06 US disclosed
US-20040143081-A1 Novel silicon compounds and process for preparation thereof JNC CORPORATION (JP) 2004-07-22 US disclosed
US-5527938-A FRIEDEL-CRAFT ALKYLATION OF AROMATIC COMPOUNDS WITH ALLYLCHLOROSILANES USING LEWIS ACID CATALYST KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1996-06-18 US disclosed
US-5523444-A REACTING (SUBSTITUTED)AROMATIC COMPOUNDS WITH ALLYLCHLOROSILANES IN PRESENCE OF LEWIS ACID CATALYSTS KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1996-06-04 US disclosed