Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.49 |
| ▸ | NOS1 | P29475 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | DRD4 | P21917 | 6/20 | 0.49 |
| ▸ | DRD3 | P35462 | 6/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498487 | 0.85 | DRD2 (0.50) | DRD2DRD4DRD3HTR1AGPR55 | |
| SCHEMBL5973289 | 0.84 | HTR1A (0.50) | DRD2DRD4DRD3HTR1AGPR55 | |
| SCHEMBL8625517 | 0.83 | PRMT6 (0.57) | NOS3NOS1PRMT6EPHX2CYP11B1 | |
| SCHEMBL16135138 | 0.81 | GPR55 (0.59) | DRD2DRD4DRD3PRMT6HTR1A | |
| SCHEMBL14079723 | 0.81 | NOS3 (0.47) | NOS3NOS1PRMT6EPHX2GPR55 | |
| SCHEMBL7395929 | 0.78 | HTR1A (0.48) | DRD2DRD4DRD3HTR1AGPR55 | |
| SCHEMBL16619652 | 0.78 | CYP11B1 (0.41) | NOS1PRMT6EPHX2CYP11B1CYP11B2 | |
| SCHEMBL7392994 | 0.78 | KCNH2 (0.50) | DRD2DRD4DRD3HTR1AGPR55 | |
| SCHEMBL16366969 | 0.78 | DRD2 (0.50) | DRD2DRD4DRD3HTR1AGPR55 | |
| SCHEMBL4418405 | 0.78 | TAAR1 (0.54) | NOS3NOS1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767132-A | CENTRAL NERVOUS SYSTEM | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-06-16 | — | — | US | claimed |
| CN-109745313-A | The D3 dopamine-receptor stimulant for treating dyskinesia in Parkinson's disease | 德雷克塞尔大学 | 2019-05-14 | — | — | CN | disclosed |
| CN-103347517-B | Treatment of dyskinesia in Parkinson's disease D3Dopamine receptor agonists | 德雷克塞尔大学 | 2018-10-02 | — | — | CN | disclosed |
| EP-1408964-B1 | USE OF 2- 5-(4-FLUOROPHENYL)-3-PYRIDYLMETHYLAMINOMETHYL|-CHROMANE AND ITS PHYSIOLOGICALLY ACCEPTABLE SALTS | MERCK PATENT GMBH (DE) | 2007-01-24 | — | — | EP | disclosed |
| US-5767132-A | CENTRAL NERVOUS SYSTEM | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-06-16 | — | — | US | disclosed |