Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 7/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507890 | 0.89 | SLC6A3 (0.31) | CYP3A4SLC6A3 | |
| SCHEMBL2993665 | 0.79 | PPARA (0.43) | FBP1ABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL4065131 | 0.76 | SLC6A3 (0.33) | SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL5511640 | 0.71 | HSD11B1 (0.45) | FBP1ABCB11CYP1A2CYP3A4TSHR | |
| SCHEMBL4241674 | 0.70 | — | — | |
| SCHEMBL3001081 | 0.68 | ESR1 (0.43) | SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL2995580 | 0.68 | CHRM1 (0.40) | SLC6A3SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL3001203 | 0.66 | FFAR4 (0.43) | — | |
| SCHEMBL2990531 | 0.65 | LIPC (0.38) | SLC6A3SLC6A2ALDH1A1 | |
| SCHEMBL4070181 | 0.65 | SLC6A3 (0.33) | SLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |