Sugi Predict

Sugi Predict / Compounds / SCHEMBL550845

SCHEMBL550845

SCHEMBL550845

O=[N+]([O-])c1c(F)cccc1Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.43
▸ TSHR P16473 4/20 0.43
▸ TDP1 Q9NUW8 3/20 0.43
▸ MAPT P10636 3/20 0.42
▸ GRIN2D O15399 1/20 0.41
▸ GRIN3B O60391 1/20 0.41
▸ GRIN1 Q05586 1/20 0.41
▸ GRIN2A Q12879 1/20 0.41
▸ GRIN2B Q13224 1/20 0.41
▸ GRIN2C Q14957 1/20 0.41
▸ GRIN3A Q8TCU5 1/20 0.41
▸ MAPK1 P28482 2/20 0.41
▸ POLB P06746 1/20 0.41
▸ HSP90AA1 P07900 1/20 0.41
▸ ARNT P27540 1/20 0.40
▸ EPAS1 Q99814 1/20 0.40
▸ TAAR1 Q96RJ0 1/20 0.38
▸ GPR35 Q9HC97 1/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ NPC1 O15118 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31050080 1.00 ALDH1A1 (0.43) ALDH1A1TSHRTDP1MAPTGRIN2D
SCHEMBL240574 0.84 TDP1 (0.52) ALDH1A1TSHRTDP1MAPTGPR35
SCHEMBL670917 0.84 TSHR (0.58) ALDH1A1TSHRTDP1GRIN2DGRIN3B
SCHEMBL27756441 0.83 MAPT (0.39) ALDH1A1TSHRTDP1MAPTGRIN2D
SCHEMBL27756639 0.83 NPC1 (0.40) ALDH1A1TSHRTDP1MAPTGRIN2D
SCHEMBL2498374 0.82 ARNT (0.38) ALDH1A1TSHRTDP1MAPTGRIN2D
SCHEMBL2500102 0.82 TSHR (0.40) ALDH1A1TSHRTDP1MAPTGRIN2D
SCHEMBL14405284 0.79 TAAR1 (0.38) ALDH1A1TDP1MAPTMAPK1POLB
SCHEMBL5614002 0.78 LMNA (0.49) ALDH1A1TSHRTDP1MAPTMAPK1
SCHEMBL41402 0.77 TSHR (0.59) ALDH1A1TSHRTDP1MAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 260 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116903445-A Preparation method of 2-fluoro-6-chlorophenol 江苏乾元生物科技有限公司 2023-10-20 — — CN claimed
CN-101374799-B Process for preparing substituted biphenyls BASF SE 2012-05-23 — — CN claimed
US-7709684-B2 Process for preparing substituted biphenyls BASF SE (DE) 2010-05-04 — — US claimed
EP-2029519-A1 PROCESS FOR PREPARING SUBSTITUTED BIPHENYLS BASF SE (DE) 2009-03-04 — — EP claimed
CN-101374799-A Process for preparing substituted biphenyls BASF SE (DE) 2009-02-25 — — CN claimed
US-20090005597-A1 Process for Preparing Substituted Biphenyls BASF SE (DE) 2009-01-01 — — US claimed
WO-2007138089-A1 PROCESS FOR PREPARING SUBSTITUTED BIPHENYLS BASF SE (DE) 2007-12-06 — — WO claimed
EP-3233077-B1 DOPAMINE D2 RECEPTOR LIGANDS BROAD INST INC (US) 2026-05-06 — — EP disclosed
US-20260097034-A1 METALLOENZYME INHIBITOR COMPOUNDS CORXEL PHARMACEUTICALS HONG KONG LTD (HK) 2026-04-09 — — US disclosed
EP-4676590-A1 PHOSPHODIESTERASE 3 (PDE3) INHIBITORS Zoetis Services LLC (US) 2026-01-14 — — EP disclosed
EP-4667460-A1 MIR-124 INDUCER, AND PREPARATION METHOD THEREFOR AND USE THEREOF Nanjing Synnocare Pharmaceutical Technology Co., Ltd. (CN) 2025-12-24 — — EP disclosed
US-20250340510-A1 Substituted Phenylbenzenesulfonamide Derivatives and Uses Thereof NINE SQUARE THERAPEUTICS CORPORATION (US) 2025-11-06 — — US disclosed
US-12458642-B2 Metalloenzyme inhibitor compounds CORXEL PHARMACEUTICALS HONG KONG LIMITED (HK) 2025-11-04 — — US disclosed
US-4806630-A Catalytic polymerization of carbon monoxide and olefin, with organo nitro or organo nitrite compound additive SHELL OIL COMPANY (US) 1989-02-21 — — US disclosed
US-4551264-A Polyhalogenoaromatic compounds for liquid crystal compositions MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1985-11-05 — — US disclosed
US-4182872-A CORRESPONDING 4-CARBOBENZOXY COMPOUNDS, 2,3,4,4A-TETRAHYDRO-1H-PYRAZINO(1,2-A)QUINOXALIN-5(6H)-ONES, 2,3,4,4A,5,6-HEXAHYDRO-1H-PYRAZINO(1,2-A)QUINOXALINES, HYPOTENSIVE AMERICAN HOME PRODUCTS CORPORATION (US) 1980-01-08 — — US disclosed
US-4182869-A HYPOTENSIVE AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1980-01-08 — — US disclosed
US-4138567-A HYPOTENSIVE AMERICAN HOME PRODUCTS CORPORATION (US) 1979-02-06 — — US disclosed
US-4089958-A HYPOTENSIVE AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1978-05-16 — — US disclosed
US-4032639-A 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension AMERICAN HOME PRODUCTS CORPORATION (US) 1977-06-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090005597-A1 Process for Preparing Substituted Biphenyls CBR3, HRH3, CBR1 ALDH1A1 1911/4885TSHR 14/4885TDP1 1355/4885
US-12458642-B2 Metalloenzyme inhibitor compounds CYP11B2, CYP11B1, HSD11B2 ALDH1A1 232/4885TSHR 2512/4885TDP1 2721/4885
US-20260097034-A1 METALLOENZYME INHIBITOR COMPOUNDS CPN1, TPP1, DPP4 ALDH1A1 189/4885TSHR 1191/4885TDP1 692/4885
US-20250340510-A1 Substituted Phenylbenzenesulfonamide Derivatives and Uses Thereof TRPM2, TRPM6, TRPM5 ALDH1A1 3137/4885TSHR 4552/4885TDP1 1143/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.