Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.32 |
| ▸ | TET3 | O43151 | 1/20 | 0.32 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL9139201 | 0.97 | TP53 (0.42) | TP53ALDH1A1TDP1TGFBR1FFAR3 | |
| Methacrylic Acid SCHEMBL19181034 | 0.97 | TP53 (0.42) | TP53ALDH1A1TDP1TGFBR1FFAR3 | |
| Methacrylic Acid SCHEMBL19181035 | 0.97 | TP53 (0.42) | TP53ALDH1A1TDP1TGFBR1FFAR3 | |
| Methacrylic Acid SCHEMBL28295764 | 0.85 | CTH (0.37) | TP53ALDH1A1TDP1TGFBR1FFAR3 | |
| Methacrylic Acid SCHEMBL30732488 | 0.85 | PAOX (0.42) | TP53ALDH1A1TDP1TGFBR1TSHR | |
| Methacrylic Acid SCHEMBL28840208 | 0.84 | TGFBR1 (0.34) | ALDH1A1TGFBR1TSHRALOX15 | |
| Methacrylic Acid SCHEMBL331477 | 0.83 | ALDH1A1 (0.38) | ALDH1A1TDP1TGFBR1FFAR3THRB | |
| Pyruvate SCHEMBL21145192 | 0.82 | TP53 (0.50) | TP53ALDH1A1TDP1FFAR3LCK | |
| Oxalic Acid SCHEMBL5875441 | 0.82 | TP53 (0.57) | TP53ALDH1A1TDP1FFAR3TSHR | |
| Methacrylic Acid SCHEMBL129271 | 0.82 | TDP1 (0.44) | ALDH1A1TDP1TGFBR1FFAR3THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111378077-B | Low-temperature-sensitivity polycarboxylic acid superplasticizer and preparation method thereof | 江苏苏博特新材料股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-111635552-A | Preparation method and application of myclobutanil molecularly imprinted inverse opal photonic crystal hydrogel sensor | 昆明理工大学 | 2020-09-08 | — | — | CN | claimed |
| CN-108165328-A | A kind of compound low-sulfur high performance diesel antiwear additive | 中海油天津化工研究设计院有限公司 | 2018-06-15 | — | — | CN | claimed |
| CN-102492106-A | Large molecular emulsifier with switchable surface activity and application thereof to preparation of rubber latex | UNIV ZHEJIANG | 2012-06-13 | — | — | CN | claimed |
| US-20070043142-A1 | DENTAL COMPOSITIONS BASED ON NANOFIBER REINFORCEMENT | BJM LABORATORIES LTD. (IL) | 2007-02-22 | — | — | US | claimed |
| CN-1043755-C | Explosive composition | ICI AUSTRALIA OPERATIONS (AU) | 1999-06-23 | — | — | CN | claimed |
| CN-88100209-A | EXPLOSIVE COMPOSITION | — | 1988-08-10 | — | — | CN | claimed |
| CN-120129707-A | Solid particles of silicone-functional copolymer, method for producing same, and cosmetic containing same | 陶氏东丽株式会社 | 2025-06-10 | — | — | CN | disclosed |
| CN-119523006-A | Preparation method of dietary fiber coffee solid beverage | 广东四季优美实业有限公司 | 2025-02-28 | — | — | CN | disclosed |
| US-20240392165-A1 | CURABLE ORGANOPOLYSILOXANE COMPOSITION, ORGANOPOLYSILOXANE ADHESIVE LAYER OBTAINED BY CURING SAME, AND LAMINATE | DOW TORAY CO LTD (JP) | 2024-11-28 | — | — | US | disclosed |
| US-20240384138-A1 | CURABLE ORGANOPOLYSILOXANE COMPOSITION, SLIGHTLY-ADHESIVE ORGANOPOLYSILOXANE ADHESIVE AGENT LAYER OBTAINED BY CURING SAME, AND LAMINATE | DOW TORAY CO LTD (JP) | 2024-11-21 | — | — | US | disclosed |
| US-20240376347-A1 | CURABLE HOT MELT ORGANOPOLYSILOXANE COMPOSITION, CURED PRODUCT THEREOF AND METHOD FOR PRODUCING FILM, ETC. COMPRISING SAME | DOW TORAY CO LTD (JP) | 2024-11-14 | — | — | US | disclosed |
| US-12023403-B2 | Oil-in-water type emulsion cosmetics | DOW TORAY CO., LTD. (JP) | 2024-07-02 | — | — | US | disclosed |
| CN-102928908-A | Stretched optical film and polarizing plate and image display device using the same | NIPPON CATALYTIC CHEM IND | 2013-02-13 | — | — | CN | disclosed |
| CN-102492106-A | Large molecular emulsifier with switchable surface activity and application thereof to preparation of rubber latex | UNIV ZHEJIANG | 2012-06-13 | — | — | CN | disclosed |
| CN-102432760-A | Quaternary amine konjac glucomannan adduct and preparation method and application thereof | DONGHUI MA | 2012-05-02 | — | — | CN | disclosed |
| US-5847071-A | Photosensitive resin composition | HITACHI, CHEMICAL CO., LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| US-5668248-A | POLYAMIC ACID ESTERS | HITACHI CHEMICAL CO., LTD. (JP) | 1997-09-16 | — | — | US | disclosed |
| US-5472823-A | Polyamic acids | HITACHI CHEMICAL CO., LTD. (JP) | 1995-12-05 | — | — | US | disclosed |
| US-5221335-A | Stabilized pigmented hot melt ink containing nitrogen-modified acrylate polymer as dispersion-stabilizer agent | COATES ELECTROGRAPHICS LIMITED (GB) | 1993-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12023403-B2 | Oil-in-water type emulsion cosmetics | CUTA, MITF, POLQ | TP53 14/4885ALDH1A1 3811/4885TDP1 2911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.