Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5540308 | 0.75 | DRD2 (0.36) | MAPTPOLBRORCNPC1SMN1; SMN2 | |
| SCHEMBL5540355 | 0.74 | CA1 (0.39) | MAPTPOLBNPC1LMNAALDH1A1 | |
| SCHEMBL5540828 | 0.73 | MAPT (0.44) | MAPTRORCLMNAALDH1A1 | |
| SCHEMBL5546893 | 0.72 | MAPT (0.40) | MAPTRORCNPC1SMN1; SMN2LMNA | |
| SCHEMBL5540254 | 0.69 | RAB9A (0.37) | MAPTPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL3531915 | 0.67 | MAPK1 (0.44) | MAPTPOLBRORCSMN1; SMN2LMNA | |
| SCHEMBL5545044 | 0.66 | ALDH1A1 (0.44) | MAPTPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL5544949 | 0.66 | ALDH1A1 (0.36) | RORCNPC1SMN1; SMN2KCNQ3KCNQ2 | |
| SCHEMBL5538068 | 0.65 | MAPT (0.39) | MAPTNPC1RAB9A | |
| SCHEMBL5548146 | 0.63 | MAPT (0.48) | MAPTPOLBSMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007534719-A | — | — | 2007-11-29 | — | — | JP | claimed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | claimed |